Behavioral and Brain Sciences



Open Peer Commentary
Fitch & Denenberg: Sexual differentiation of the brain

Sexual differentiation of callosal size: Hormonal mechanisms and the choice of an animal model


M. J. Baum a1a3 and S. A. Tobet a2a3
a1 Department of Biology, Boston University, Boston, MA 02215 baum@bio.bu.edu
a2 Department of Biomedical Sciences, The Shriver Center, Waltham, MA 02254 stobet@shriver.org
a3 Program in Neuroscience, Harvard Medical School, Boston, MA 02115

Abstract

Studies of callosal sexual differentiation have concentrated on global measures of callosal size, using the rat as a model for studies of potential hormonal mechanisms. It is time to shift the study of callosal sexual differentiation to a more cellular level. Finally, there are potential problems with using the female rat as the primary model for understanding hormonal mechanisms during postnatal life.



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