The International Journal of Neuropsychopharmacology


The metabolic consequences of long-term treatment with olanzapine, quetiapine and risperidone: are there differences? 1

Herbert Y. Meltzer a1c1
a1 Vanderbilt University School of Medicine

Article author query
meltzer hy   [PubMed][Google Scholar] 

Since the increased use of clozapine for schizophrenia, beginning in 1989, followed in temporal order, by the introduction of other atypical antipsychotic drugs (APDs), e.g. risperidone, olanzapine, quetiapine, ziprasidone and aripiprazole, there has been ever-increasing interest in the effect of these antipsychotics on: (1) body mass index (BMI) and related measures of adiposity; (2) blood glucose and related measures of insulin sensitivity, including the development of type II diabetes mellitus (DM); and (3) hyperlipidaemia. Clinicians who prescribe these drugs have become particularly concerned with increasing rates of obesity and type II DM, the most immediately evident, short-term effects of possible adverse metabolic effects of these agents. At least in the USA, these metabolic effects must be evaluated in the context of the increasing BMI of the population in general, and life-style, economic, and general medical care issues, which may be contributory in patients with schizophrenia or bipolar disorder, for whom these medications are now the mainstay of treatment, having displaced the typical neuroleptic drugs in most western countries.

(Received February 15 2005)
(Reviewed February 16 2005)
(Accepted February 18 2005)

c1 Division of Psychopharmacology, Psychiatric Hospital at Vanderbilt 1601, 23rd Ave South, Nashville, TN 37212, USA. Tel.: 615 327 7049 Fax: 615 327 7093 Email:


1 See Emsley et al. (this issue). Effects of quetiapine and haloperidol on body mass index and glycaemic control: a long-term, randomized, controlled trial; Smith et al. (this issue). Clozapine, risperidone, olanzapine, and conventional antipsychotic drug effects on glucose, lipids, and leptin in schizophrenic patients.