Behavioral and Brain Sciences



Open Peer Commentary
Quartz & Sejnowski: Cognitive development

Stress, LTP, and depressive disorder


I. C. Reid a1 and C. A. Stewart a1
a1 Department of Psychiatry, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland c.a.stewart@dundee.ac.uk www.dundee.ac.uk/psychiatry

Abstract

Preoccupation with LTP as a putative memory mechanism may have retarded the consideration of pathological modulation of synaptic plasticity in clinical disorders where memory dysfunction is not a primary feature. Encouraged by Shors & Matzel's review, we consider the relationship between stress, synaptic plasticity, and depressive disorder.