Behavioral and Brain Sciences



Open Peer Commentary
Quartz & Sejnowski: Cognitive development

LTP and learning: Let's stay together


Robert D. Hawkins a1
a1 Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032 [email protected]

Abstract

The hypothesis that there is a 1:1 correspondence between LTP and learning is simplistic, and the correlation approach to testing it is therefore too limited. The alternative hypothesis that LTP plays a role in arousal is consistent with activity-dependent neuromodulation, but ignores the Hebbian properties of LTP. LTP may involve both types of mechanisms, suggesting a possible synthesis of the two hypotheses.



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