Open Peer Commentary Controversies in Neuroscience V: Persistent pain
Does central nervous system plasticity contribute to hyperalgesia?
Corey L. Cleland a1andG. F. Gebhart a1 a1 Departments of Physiology and Biophysics, and Pharmacology, The University of Iowa, Iowa City, IA 52242
corey-cleland@uiowa.edu
Abstract
Hyperalgesia can arise from peripheral sensitization, on-going
peripheral activation, and central plasticity. In the target article,
coderre & katz argue that all three mechanisms
contribute to hyperalgesia. In contrast, we believe that existing
experimental evidence suggests that central plasticity plays only
an insignificant role in most experimental models and clinical
presentations of hyperalgesia induced by tissue injury or chemical
activation of sensory receptors.
