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Dual task performance in early Alzheimer's disease, amnestic mild cognitive impairment and depression

Published online by Cambridge University Press:  15 April 2008

J. A. Lonie
Affiliation:
University of Edinburgh Division of Psychiatry, The Royal Edinburgh Hospital, Edinburgh, UK
K. M. Tierney
Affiliation:
University of Edinburgh Division of Psychiatry, The Royal Edinburgh Hospital, Edinburgh, UK
L. L. Herrmann
Affiliation:
University of Oxford Department of Psychiatry, Warneford Hospital, Oxford, UK
C. Donaghey
Affiliation:
University of Edinburgh Division of Psychiatry, The Royal Edinburgh Hospital, Edinburgh, UK
R. E. O'Carroll
Affiliation:
University of Stirling Department of Psychology, University of Stirling, Stirling, UK
A. Lee
Affiliation:
University of Edinburgh Division of Psychiatry, The Royal Edinburgh Hospital, Edinburgh, UK
K. P. Ebmeier*
Affiliation:
University of Edinburgh Division of Psychiatry, The Royal Edinburgh Hospital, Edinburgh, UK University of Oxford Department of Psychiatry, Warneford Hospital, Oxford, UK
*
*Address for correspondence: Professor K. P. Ebmeier, University of Oxford, Section of Old Age Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK. (Email: Klaus.ebmeier@psych.ox.ac.uk)

Abstract

Background

The dual task paradigm (Baddeley et al.1986; Della Sala et al.1995) has been proposed as a sensitive measure of Alzheimer's dementia, early in the disease process.

Method

We investigated this claim by administering the modified dual task paradigm (utilising a pencil-and-paper version of a tracking task) to 33 patients with amnestic mild cognitive impairment (aMCI) and 10 with very early Alzheimer's disease, as well as 21 healthy elderly subjects and 17 controls with depressive symptoms. All groups were closely matched for age and pre-morbid intellectual ability.

Results

There were no group differences in dual task performance, despite poor performance in episodic memory tests of the aMCI and early Alzheimer's disease groups. In contrast, the Alzheimer patients were specifically impaired in the trail-making test B, another commonly used test of divided attention.

Conclusions

The dual task paradigm lacks sensitivity for use in the early differential diagnosis of Alzheimer's disease.

Type
Original Articles
Copyright
Copyright © 2008 Cambridge University Press

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References

Alladi, S, Arnold, R, Mitchell, J, Nestor, PJ, Hodges, JR (2006). Mild cognitive impairment: applicability of research criteria in a memory clinic and characterization of cognitive profile. Psychological Medicine 36, 507513.CrossRefGoogle Scholar
APA (1994). Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association: Washington, DC.Google Scholar
Arnaiz, E, Blomberg, M, Fernaeus, SE, Wahlund, LO, Winbald, B, Almkvist, O (2000). Psychometric discrimination of Alzheimer's disease and mild cognitive impairment. Alzheimer's Reports 2, 97103.Google Scholar
Baddeley, AD, Baddeley, HA, Bucks, RS, Wilcock, GK (2001). Attentional control in Alzheimer's disease. Brain 124, 14921508.CrossRefGoogle ScholarPubMed
Baddeley, AD, Bressi, S, Della Sala, S, Logie, R, Spinnler, H (1991). The decline of working memory in Alzheimer's disease: a longitudinal study. Brain 114, 25212542.CrossRefGoogle ScholarPubMed
Baddeley, AD, Della Sala, S, Papagno, C, Spinnler, H (1997). Dual-task performance in dysexecutive and nondysexecutive patients with a frontal lesion. Neuropsychology 11, 187194.CrossRefGoogle ScholarPubMed
Baddeley, AD, Logie, R, Bressi, S, Della Sala, S, Spinnler, H (1986). Dementia and working memory. Quarterly Journal of Experimental Psychology Section A Human Experimental Psychology 38, 603618.CrossRefGoogle ScholarPubMed
Baudic, S, Barba, GD, Thibaudet, MC, Smagghe, A, Remy, P, Traykov, L (2006). Executive function deficits in early Alzheimer's disease and their relations with episodic memory. Archives of Clinical Neuropsychology 21, 1521.CrossRefGoogle ScholarPubMed
Blackwell, AD, Sahakian, BJ, Vesey, R, Semple, JM, Robbins, TW, Hodges, JR (2004). Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 17, 4248.CrossRefGoogle ScholarPubMed
Brandt, J (1991). The Hopkins verbal learning test: development of a new memory test with 6 equivalent forms. Clinical Neuropsychologist 5, 125142.CrossRefGoogle Scholar
Chen, P, Ratcliff, G, Belle, SH, Cauley, JA, DeKosky, ST, Ganguli, M (2000). Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented. Neurology 55, 18471853.CrossRefGoogle ScholarPubMed
Christensen, H, Griffiths, K, Mackinnon, A, Jacomb, P (1997). A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. Journal of the International Neuropsychological Society 3, 631651.CrossRefGoogle ScholarPubMed
Crossley, M, Hiscock, M (1992) Age-related differences in concurrent-task performance of normal adults: evidence for a decline in processing resources. Psychology and Aging 7, 499506.CrossRefGoogle ScholarPubMed
Crossley, M, Hiscock, M, Foreman, JB (2004). Dual-task performance in early stage dementia: differential effects for automatized and effortful processing. Journal of Clinical and Experimental Neuropsychology 26, 332346.CrossRefGoogle ScholarPubMed
Crowell, TA, Luis, CA, Vanderploeg, RD, Schinka, JA, Mullan, M (2002). Memory patterns and executive functioning in mild impairment and Alzheimer's disease. Aging Neuropsychology and Cognition 9, 288297.CrossRefGoogle Scholar
Della Sala, S (1999). Paper and Pencil Dual Task – University of Edinburgh (http://www.psy.ed.ac.uk/people/sdsala/tests/sdsdualtask). Accessed 1 February 2008.Google Scholar
Della Sala, S, Baddeley, A, Papagno, C, Spinnler, H (1995). Dual task paradigm: a means to examine the central executive. In Annals of the New York Academy of Sciences, vol. 769. Structure and Functions of the Human Prefrontal Cortex (ed. Graham, J., Holyoak, K. J. and Boller, F.), pp. 161171. New York Academy of Sciences: New York.Google Scholar
Greene, JDW, Hodges, JR, Baddeley, AD (1995). Autobiographical memory and executive function in early dementia of Alzheimer type. Neuropsychologia 33, 16471670.CrossRefGoogle ScholarPubMed
Hartley, AA, Little, DM (1999). Age related differences and similarities in dual-task interference. Journal of Experimental Psychology: General 128, 416449.CrossRefGoogle ScholarPubMed
Hasher, L, Zacks, RT (1979). Automatic and effortful processes in memory. Journal of Experimental Psychology: General 108, 356388.CrossRefGoogle Scholar
Hogervorst, E, Combrinck, M, Lapuerta, P, Rue, J, Swales, K, Budge, M (2002). The Hopkins verbal learning testing and screening for dementia. Dementia and Geriatric Cognitive Disorders 13, 1320.CrossRefGoogle ScholarPubMed
Holtzer, R, Burright, RG, Donovick, PJ (2004). The sensitivity of dual-task performance to cognitive status in aging. Journal of the International Neuropsychological Society 10, 230238.CrossRefGoogle ScholarPubMed
Lafleche, G, Albert, MS (1995). Executive function deficits in mild Alzheimer's disease. Neuropsychology 9, 313320.CrossRefGoogle Scholar
Logie, RH, Cocchini, G, Della Sala, S, Baddeley, AD (2004). Is there a specific executive capacity for dual task coordination? Evidence from Alzheimer's disease. Neuropsychology 18, 504513.CrossRefGoogle Scholar
MacPherson, SE, Della Sala, S, Logie, RH (2004). Dual-task interference of encoding and retrieval processes in healthy and impaired working memory. Cortex 40, 183184.CrossRefGoogle ScholarPubMed
Mahurin, RK, Velligan, DI, Hazleton, B, Davis, JM, Eckert, S, Miller, AL (2006). Trail making test errors and executive function in schizophrenia and depression. Clinical Neuropsychologist 20, 271288.CrossRefGoogle ScholarPubMed
Mathuranath, PS, Nestor, PJ, Berrios, GE, Rakowicz, W, Hodges, JR (2000). A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia. Neurology 55, 16131620.CrossRefGoogle ScholarPubMed
Mattis, S (1988). Dementia Rating Scale (DRS). Psychological Assessment Resources, Inc.: Odessa, FL.Google Scholar
McKhann, G, Drachman, D, Folstein, M, Katzmann, R, Price, D, Stadlan, EM (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRADA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939944.CrossRefGoogle Scholar
Nathan, J, Wilkinson, D, Stammers, S, Low, JL (2001). The role of tests of frontal executive functioning in the detection of mild dementia. International Journal of Geriatric Psychiatry 16, 1826.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Nebes, RD, Butters, MA, Houck, PR, Zmuda, MD, Aizenstein, H, Pollock, BG, Muslant, BH, Reynolds, CF (2001). Dual-task performance in depressed geriatric patients. Psychiatry Research 102, 139151.CrossRefGoogle ScholarPubMed
Nelson, HE, Willison, JR (1991). The Revised National Adult Reading Test – Test Manual. NFER-Nelson: Windsor, UK.Google Scholar
Parasuraman, R, Haxby, J (1993). Attention and brain function in Alzheimer's disease: a review. Neuropsychology 7, 242272.CrossRefGoogle Scholar
Perry, RJ, Hodges, JR (1999). Attention and executive deficits in Alzheimer's disease: a critical review. Brain 122, 383404.CrossRefGoogle ScholarPubMed
Perry, RJ, Watson, P, Hodges, JR (2000). The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer's disease: relationship to episodic and semantic memory impairment. Neuropsychologia 38, 252271.CrossRefGoogle ScholarPubMed
Petersen, RC (2005). Mild cognitive impairment as a clinical entity and treatment target. Archives of Neurology 62, 11601163.CrossRefGoogle ScholarPubMed
Petersen, RC, Doody, R, Kurz, A, Morris, JC, Rabins, JC, Ritchie, K, Rossor, M, Thal, L, Winbald, B (2001). Current concepts in mild cognitive impairment. Archives of Neurology 58, 19851992.CrossRefGoogle ScholarPubMed
Petersen, RC, O'Brien, J (2006). Mild cognitive impairment should be considered for DSM-V. Journal of Geriatric Psychiatry and Neurology, 19, 147154.CrossRefGoogle ScholarPubMed
Petersen, RC, Smith, GE, Waring, SC, Ivrnik, RJ, Kokmen, E (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology 56, 303308.CrossRefGoogle ScholarPubMed
Reitan, RM (1985). Halstead–Reitan Neuropsychological Test Battery. Reitan Neuropsychology Laboratory Press: Tucson, AZ.Google Scholar
Sebastian, MV, Menor, J, Elousa, MR (2006). Attentional dysfunction of the central executive in AD: evidence from dual task and perseveration errors. Cortex 42, 10151020.CrossRefGoogle ScholarPubMed
Stokholm, J, Vogel, A, Gade, A, Waldemar, G (2006). Heterogeneity in executive impairment in patients with very mild Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 22, 5459.CrossRefGoogle ScholarPubMed
Storandt, M, Grant, EA, Miller, JP, Morris, JC (2006). Longitudinal course and neuropathologic outcomes in original vs. revised MCI and in pre-MCI. Neurology 67, 467473.CrossRefGoogle ScholarPubMed
Swainson, R, Hodges, JR, Galton, CJ, Semple, J, Michael, A, Dunn, BD, Iddon, JL, Robbins, TW, Sahakian, BJ (2001). Early detection and differential diagnosis of AD and depression with neuropsychological tasks. Dementia and Geriatric Cognitive Disorders 12, 265280.CrossRefGoogle ScholarPubMed
Wimo, A, Winbald, B, Aguero-Torres, H, von Strauss, E (2003). The magnitude of dementia occurrence in the world. Alzheimer's Disease and Associated Disorders 17, 6367.CrossRefGoogle ScholarPubMed