Behavioral and Brain Sciences

Open Peer Commentary
Quartz & Sejnowski: Cognitive development

State-dependent suppression of LTP induction after learning: Relation to phasic hippocampal network events

Clive R. Bramham a1
a1 Department of Physiology, University of Bergen, N-5009 Bergen, Norway [email protected]


This commentary argues that (1) arousal is not sufficient to induce LTP in the hippocampus, (2) learning can profoundly modulate synaptic plasticity in a state-dependent manner without affecting baseline synaptic efficacy, and (3) unilateral, synapse-specific LTP induction triggers an interhippocampal communication manifested as bilateral increases in gene expression at multiple sites in the hippocampal network.