Journal of the International Neuropsychological Society



Verbal memory in first-episode schizophrenia: Heterogeneity in performance?


JASPER  NUYEN  a1 , MARGRIET M.  SITSKOORN  a1 c1 , WIEPKE  CAHN  a1 and RENÉ S.  KAHN  a1
a1 Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, the Netherlands

Article author query
nuyen j   [PubMed][Google Scholar] 
sitskoorn mm   [PubMed][Google Scholar] 
cahn w   [PubMed][Google Scholar] 
kahn rs   [PubMed][Google Scholar] 

Abstract

It is unclear if the commonly observed “subcortical” verbal memory profile in schizophrenic patients is present at the onset of the disease. Therefore, the performance of 43 first-episode patients with schizophrenia or schizophreniform disorder on the Dutch version of the California Verbal Learning Test (VLGT) was compared to that of 43 normal comparison participants. We hypothesized that the first-episode patients would exhibit a “subcortical” memory profile, that is, they would show a primary retrieval deficit. This hypothesis was not confirmed: the patients displayed a profile suggestive of a prominent storage deficit, that is, a “cortical” memory profile. Subsequently, patients' VLGT performance was cluster analyzed to determine whether subgroups could be identified exhibiting a cortical, subcortical, and normal profile, respectively. Two subgroups (N = 22; N = 13) exhibited memory impairments, while one subgroup (N = 8) was unimpaired. The memory profiles of the two impaired subgroups differed both qualitatively and quantitatively, but did not conform neatly to a cortical and a subcortical profile. Demographic and verbal fluency data provided limited validation of the subgroup classification. Our results may suggest that combining the verbal memory performance of first-episode patients obscures meaningful heterogeneity. Alternatively, the cluster solution could merely reflect a continuum of severity. (JINS, 2005, 11, 152–162.)

(Received April 25 2003)
(Revised July 2 2004)
(Accepted July 20 2004)


Key Words: First-episode schizophrenia; Verbal memory profiles; Heterogeneity; California Verbal Learning Test.

Correspondence:
c1 Address correspondence and reprint requests to: Margriet M. Sitskoorn, Director, Cognitive Neuroscience Unit, Department of Psychiatry, University Medical Center Utrecht (HPN B.01.206), P.O. Box 85500, Utrecht, 3508 GA, The Netherlands. E-mail: M.Sitskoorn@azu.nl