Epidemiology and Infection

Original Papers

Viral infections

Molecular characterization of the E gene of dengue virus type 1 isolated in Guangdong province, China, in 2006

K. ZHENGa1, H.-Q. ZHOUa1, J. YANa1, C.-W. KEa1 c1, A. MAEDAa2, J. MAEDAa2, I. TAKASHIMAa3, I. KURANEa4, H. MAa5 and X.-M. XIEa1

a1 Center for Diseases Control and Prevention of Guangdong province, Guangzhou, PR China

a2 Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

a3 Laboratory of Veterinary Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

a4 Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

a5 Zhuhai Entry-Exit Inspection and Quarantine Bureau, Guangdong province, Zhuhai, PR China

SUMMARY

We determined the genetic relationships and origin of the dengue virus (DENV) responsible for an outbreak of dengue fever (DF) in Guangdong province, China, in 2006. Five DENV type 1 (DENV-1) isolates were obtained from human serum samples collected from DF patients during the outbreak. The nucleotide sequences of the E (envelope) gene were compared with those of 48 previous DENV-1 isolates: 18 from Guangdong province, one from Fujian province, one from Zhejiang province, and 28 from other countries in the South Asian region. The results suggested that four DENV-1 isolates identified in Guangdong province in 2006 might be in general circulation there, although these DENV-1 viruses may have been originally introduced into the province from other countries. In contrast, one isolate from Guangzhou city in 2006, may have been introduced by a recently imported case from Cambodia.

(Accepted February 27 2008)

(Online publication April 04 2008)

Correspondence:

c1 Author for correspondence: Dr C.-W. Ke, Center for Diseases Control and Prevention of Guangdong Province, Guangzhou 510300, PR China. (Email: kecw1965@yahoo.com.cn)

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