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Survival and proliferative roles of erythropoietin beyond the erythroid lineage

Published online by Cambridge University Press:  01 December 2008

Constance Tom Noguchi ,
Li Wang ,
Heather M. Rogers ,
Ruifeng Teng  and
Yi Jia
Constance Tom Noguchi*
Affiliation:
Molecular Medicine Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD, USA.
Li Wang
Affiliation:
Molecular Medicine Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD, USA.
Heather M. Rogers
Affiliation:
Molecular Medicine Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD, USA.
Ruifeng Teng
Affiliation:
Molecular Medicine Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD, USA.
Yi Jia
Affiliation:
Molecular Medicine Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD, USA.
*
*Corresponding author: Constance Tom Noguchi, Molecular Medicine Branch, NIDDK, National Institutes of Health, Building 10, Room 9N319, 10 CENTER DR MSC-1822, Bethesda, MD 20892-1822, USA. Tel: +1 301 496 1163; Fax: +1 301 402 0101; E-mail: cnoguchi@helix.nih.gov
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Abstract

Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO for mature red blood cell production has been well established. The cloning of the EPO gene and production of recombinant human EPO led to the widespread use of EPO in treating patients with anaemia. However, the biological activity of EPO is not restricted to regulation of erythropoiesis. EPO receptor (EPOR) expression is also found in endothelial, brain, cardiovascular and other tissues, although at levels considerably lower than that of erythroid progenitor cells. This review discusses the survival and proliferative activity of EPO that extends beyond erythroid progenitor cells. Loss of EpoR expression in mouse models provides evidence for the role of endogenous EPO signalling in nonhaematopoietic tissue during development or for tissue maintenance and/or repair. Determining the extent and distribution of receptor expression provides insights into the potential protective activity of EPO in brain, heart and other nonhaematopoietic tissues.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 10 , October 2008 , e36
Copyright
Published by Cambridge University Press. Work by a US government employee - not in copyright in the USA.

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References

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Further reading, resources and contacts

This page from the Information Center for Sickle Cell and Thalassemic Disorders website includes an overview of the relationship between iron and erythropoietin activity in red blood cell production:

Hodges, V.M. et al. (2007) Pathophysiology of anemia and erythorcytosis. Crit Rev Oncol Hematol 64, 139-158CrossRefGoogle Scholar
Sasaki, R. (2003) Pleiotropic functions of erythropoietin. Intern Med 42, 142-149CrossRefGoogle ScholarPubMed
Jelkmann, W. et al. (2008) The erythropoietin receptor in normal and cancer tissues. Crit Rev Oncol/Hematol 67, 39-61CrossRefGoogle ScholarPubMed
Sytkowski, A.J. (2004) Erythropoietin: Blood, Brain and Beyond, Wiley-VCH, Weinheim, GermanyCrossRefGoogle Scholar
http://sickle.bwh.harvard.edu/iron_epo.htmlGoogle Scholar
Hodges, V.M. et al. (2007) Pathophysiology of anemia and erythorcytosis. Crit Rev Oncol Hematol 64, 139-158CrossRefGoogle Scholar
Sasaki, R. (2003) Pleiotropic functions of erythropoietin. Intern Med 42, 142-149CrossRefGoogle ScholarPubMed
Jelkmann, W. et al. (2008) The erythropoietin receptor in normal and cancer tissues. Crit Rev Oncol/Hematol 67, 39-61CrossRefGoogle ScholarPubMed
Sytkowski, A.J. (2004) Erythropoietin: Blood, Brain and Beyond, Wiley-VCH, Weinheim, GermanyCrossRefGoogle Scholar
http://sickle.bwh.harvard.edu/iron_epo.htmlGoogle Scholar