Journal of the International Neuropsychological Society


Quality of life, emotional, and cognitive function following acute respiratory distress syndrome

RAMONA O.  HOPKINS  a1 a2 c1 , LINDELL K.  WEAVER  a1 a3 , KAREN J.  CHAN  a4 and JAMES F.  ORME  Jr. a1 a3
a1 Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah
a2 Psychology Department and Neuroscience Center, Brigham Young University, Provo, Utah
a3 University of Utah School of Medicine, Salt Lake City, Utah
a4 Statistical Data Center, LDS Hospital, Salt Lake City, Utah

Article author query
hopkins ro   [PubMed][Google Scholar] 
weaver lk   [PubMed][Google Scholar] 
chan kj   [PubMed][Google Scholar] 
orme jf   [PubMed][Google Scholar] 


Acute Respiratory Distress Syndrome (ARDS) is characterized by lung injury and hypoxemia, has a high mortality rate, and is associated with significant morbidity including cognitive and emotional sequelae and decreased quality of life. There is limited information regarding which of these factors are associated with decreased quality of life. This study assessed the relationships between quality of life, cognitive and emotional function in ARDS survivors at 1-year post-hospital discharge. Sixty-six ARDS survivors were administered a battery of neuropsychological tests, measures of emotional function and quality of life 1 year post-hospital discharge. At 1 year 45% of the ARDS patients had cognitive sequelae and 29% had mild to moderate symptoms of depression and anxiety. Depression, anxiety, and intensive care unit length of stay were significantly correlated with decreased quality of life. Cognitive impairments did not correlate with decreased quality of life. Illness severity and emotional function, but not cognitive sequelae, are associated with decreased quality of life 1 year following ARDS. ARDS is common and may result in significant cognitive and emotional morbidity and decreased quality of life. (JINS, 2004, 10, 1005–1017.)

(Received January 9 2004)
(Revised June 21 2004)
(Accepted June 22 2004)

Key Words: Hypoxemia; Quality of life; Critical illness; Cognitive sequelae; Affect.

c1 Reprint requests to: Ramona O. Hopkins, Ph.D., Psychology Department, 1122 SWKT, Brigham Young University, Provo, UT 84602. E-mail: