Journal of the International Neuropsychological Society



SYMPOSIA ARTICLE

Long-term neuropsychological outcomes of very low birth weight: Associations with early risks for periventricular brain insults


H. GERRY  TAYLOR  a1 c1 , NORI  MINICH  a1 , BARBARA  BANGERT  a2 , PAULINE A.  FILIPEK  a3 and MAUREEN  HACK  a1
a1 Department of Pediatrics, Case Western Reserve University and Rainbow Babies & Children's Hospital, University Hospitals of Cleveland, Cleveland, Ohio
a2 Department of Radiology & Neurosurgery, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio
a3 Departments of Pediatrics & Neurology, University of California Irvine Medical Center, Irvine, California

Article author query
taylor hg   [PubMed][Google Scholar] 
minich n   [PubMed][Google Scholar] 
bangert b   [PubMed][Google Scholar] 
filipek pa   [PubMed][Google Scholar] 
hack m   [PubMed][Google Scholar] 

Abstract

Few follow-up studies of children with very low birth weight (VLBW, <1,500 g) have examined neuropsychological sequelae at later ages or neonatal risks as predictors of these outcomes. The present study assessed cognitive skills at mean age 16 years in 48 participants with <750 g birth weight, 47 with 750–1,499 g birth weight, and 52 term-born controls. Our major objectives were to delineate the long-term cognitive consequences of VLBW, and to determine if risks for periventricular brain insults accounted for variations in outcomes. Analysis revealed poorer outcomes for the <750 g group than for term-born controls on nearly all measures, with specific impairments in visual–motor skills, spatial memory, and executive function. Predictors of outcome for participants with VLBW included lower birth weight, lower weight for gestational age, and a longer period of oxygen requirement for chronic lung disease. The longer-term consequences of VLBW are consistent with expectations based on early brain pathology and suggest limitations to functional plasticity. (JINS, 2004, 10, 987–1004.)

(Received February 2 2004)
(Revised May 7 2004)
(Accepted June 4 2004)


Key Words: Neuropsychological consequences; Low birth weight; Hypoxic-ischemia; Neonatal risks.

Correspondence:
c1 Reprint requests to: H. Gerry Taylor, Ph.D., Department of Pediatrics, Rainbow Babies & Children's Hospital, 11100 Euclid Ave., Cleveland, OH 44106-6038. E-mail: hgt2@po.cwru.edu


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