Intake of nutrient supplements affects multiplication of Leishmania donovani in hamsters
The role of the essential nutrients, vitamins A,B (complex), C and E and iron, as prophylactic as well as supportive therapy in experimental visceral leishmaniasis (VL), was studied in hamsters. Prophylactic administration of vitamin C (50, 100 and 250 mg/kg) from day15 to day 0 (15 doses) significantly reduced the intake of Leishmania donovani in hamsters but had no therapeutic effect. In contrast, vitamins A,B complex and E and iron, whether used prophylactically or therapeutically, promoted parasite multiplication. The efficacy of sodium stibogluconate, a reference antileishmanial drug, was appreciably improved in animals administered prophylactically with vitamin C. However, supplementation of vitamin C during established infections resulted in reduced drug action. The results show that the prophylactic use of vitamin C may prevent the onset of leishmania infection and cautions against the indiscriminate use of nutrient supplements such as vitamin A, B complex, and E and iron in VL endemic areas.(Received February 15 2004)
(Revised May 4 2004)
(Accepted May 7 2004)
Key Words: Leishmania donovani; hamster; vitamin A; vitamin B complex; vitamin C; vitamin E; iron; sodium stibogluconate.
c1 Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India. Tel: +91 0522 212411 212418. Ext. 4398. Fax: +91 0522 223405/223938. E-mail: firstname.lastname@example.orgemail@example.com