Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-25T05:54:57.606Z Has data issue: false hasContentIssue false
  • English
  • Français

Definition and estimation of an actual reproduction number describing past infectious disease transmission: application to HIV epidemics among homosexual men in Denmark, Norway and Sweden

Published online by Cambridge University Press:  16 November 2004

E. J. AMUNDSEN ,
H. STIGUM ,
J.-A. RØTTINGEN  and
O. O. AALEN
E. J. AMUNDSEN
Affiliation:
Norwegian Institute for Alcohol and Drug Research (SIRUS), Oslo, Norway Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway Section of Medical Statistics, University of Oslo, Oslo, Norway
H. STIGUM
Affiliation:
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
J.-A. RØTTINGEN
Affiliation:
Institute for Nutrition Research, University of Oslo, Oslo, Norway Division for Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
O. O. AALEN
Affiliation:
Section of Medical Statistics, University of Oslo, Oslo, Norway
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Prevalence and incidence measures are the common way to describe epidemics. The reproduction number supplies information on the potential for growth or decline of an epidemic. We define an actual reproduction number for infectious disease transmission that has taken place. An estimator is suggested, based on the number of new infections observed in a given time-interval, the number of those infected at the start of the interval, and the length of the infectious period. That estimator is applied to HIV among men having sex with other men over the period, 1977–1995, in Scandinavia. The actual reproduction number was estimated with acceptable certainty from the period, 1981–1982, yielding a value of 15 secondary cases. A value of less than one secondary case was assessed for the period, 1988–1995, in Denmark and Sweden. The actual reproduction number gives us some additional understanding of the dynamics of epidemics, compared with prevalence and incidence curves.

Type
Research Article
Information
Epidemiology & Infection , Volume 132 , Issue 6 , December 2004 , pp. 1139 - 1149
Copyright
© 2004 Cambridge University Press