Epidemiology and Infection

Review Article

Declining hepatitis A seroprevalence: a global review and analysis

K. H. JACOBSEN a1c1 and J. S. KOOPMAN a1
a1 Department of Epidemiology, University of Michigan School of Public Health, MI, USA

Article author query
jacobsen kh   [PubMed][Google Scholar] 
koopman js   [PubMed][Google Scholar] 


Hepatitis A virus (HAV) is spread by faecal–oral contact or ingestion of contaminated food or water. Lifelong immunity is conferred by infection or vaccination, so anti-HAV seroprevalence studies can be used to indicate which populations are susceptible to infection. Seroprevalence rates are highly correlated with socioeconomic status and access to clean water and sanitation. Increasing household income, education, water quality and quantity, sanitation, and hygiene leads to decreases in HAV prevalence. Japan, Australia, New Zealand, Canada, the United States, and most European nations have low anti-HAV rates. Although anti-HAV rates remain high in most Latin American, Asian, and Middle Eastern nations, average seroprevalence rates are declining. Surveys from Africa generally indicate no significant decline in anti-HAV rates. Because the severity of illness increases with age, populations with a high proportion of susceptible adults should consider targeted vaccination programmes.

(Accepted June 17 2004)

c1 K. H. Jacobsen, Department of Epidemiology, 611 Church Street, Rm. 203, University of Michigan 3028, Ann Arbor, MI 48109, USA.