The Journal of Laryngology & Otology

Clinical Records

Adult cystic hygroma: successful use of OK-432 (Picibanil®)

S L Woolleya1 c1, D R K Smitha2 and S Quinea2

a1 Emergency Department, Bristol Royal Infirmary, University Hospital of Wales, Cardiff, Wales, UK

a2 Otolaryngology Department, University Hospital of Wales, Cardiff, Wales, UK


Objective: We report an adult case of cystic lymphangioma treated with OK-432 (Picibanil®).

Method: A case report and review of the literature concerning the use of OK-432 to treat cystic lymphangioma is presented.

Results: A 31-year-old woman developed a cystic lymphangioma four weeks post-partum. This was treated initially by aspiration, for diagnostic purposes. Investigation suggested that surgery would be challenging. A review of the literature demonstrated success with OK-432 in the treatment of this condition, although primarily in the paediatric population. This patient was successfully treated thus, and at the time of writing remained symptom free. A suggested management plan is outlined.

Conclusion: Treatment with OK-432 is useful in the management of cystic lymphangiomas in adults and should be considered as first line treatment.

(Accepted August 02 2007)

(Online publication April 23 2008)


c1 Address for correspondence: Dr Sarah L Woolley, Consultant, Emergency Department, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8BJ, UK. Fax: +44 117 928 2713 E-mail:


Dr S L Woolley takes responsibility for the integrity of the content of the paper.

Competing interests: None declared