Parasitology



Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns


N. B. KABATEREINE a1, B. J. VENNERVALD a2, J. H. OUMA a3, J. KEMIJUMBI a1, A. E. BUTTERWORTH a4, D. W. DUNNE a5 and A. J. C. FULFORD a5c1
a1 Vector Control Division, Ministry of Health, PO Box 1661, Kampala, Uganda
a2 Danish Bilharziasis Laboratory, DK-2920, Charlottenlund, Denmark
a3 Division of Vector Borne Diseases, Ministry of Health, PO Box, 20750, Nairobi, Kenya
a4 47, The Footpath, Coton, Cambridge CB3 7PX, UK
a5 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK

Abstract

In a fishing community on Lake Albert in Uganda the pattern of intensity of Schistosoma mansoni infection 6 months after treatment with praziquantel was found to be very similar to reinfection patterns seen in previously studied endemic communities: the profile peaks sharply at around the age of 10 years falling away rapidly to much lower levels in adults. This is in stark contrast to the patterns of water contact, which differ greatly between fishing and non-fishing communities. On Lake Albert, adults appear to be more heavily exposed than children. From these observations we conclude that adults are physiologically (perhaps immunologically) more resistant to infection after treatment than children.

(Received May 6 1998)
(Revised July 14 1998)
(Accepted July 14 1998)


Key Words: schistosomiasis; immunity; age-intensity profile; water contact.

Correspondence:
c1 Corresponding author: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. Fax: +01223 333741. E-mail: af101@cam.ac.uk


Metrics