Development and Psychopathology



Stress responsivity in children with externalizing behavior disorders


HEDDEKE  SNOEK  a1 c1 , STEPHANIE H.M.  VAN GOOZEN  a2 , WALTER  MATTHYS  a1 , JAN K.  BUITELAAR  a3 and HERMAN  VAN ENGELAND  a1
a1 University Medical Center Utrecht, Rudolf Magnus Institute for Neurosciences
a2 University of Cambridge
a3 University Medical Center Nijmegen

Article author query
snoek h   [PubMed][Google Scholar] 
van goozen shm   [PubMed][Google Scholar] 
matthys w   [PubMed][Google Scholar] 
buitelaar jk   [PubMed][Google Scholar] 
van engeland h   [PubMed][Google Scholar] 

Abstract

Patterns of lower autonomic nervous system (ANS) and hypothalamic–pituitary–adrenal (HPA) axis activity have been found in children with oppositional defiant disorder (ODD). The aim of the present study was to investigate whether children with attention-deficit/hyperactivity disorder (ADHD) differ from ODD children with (OD/AD) or without comorbid ADHD in ANS and HPA axis activity under baseline and stressful conditions. The effects of stress on cortisol, heart rate (HR), and skin conductance level (SCL) were studied in 95 children (26 normal control [NC] children and 69 child psychiatric patients referred for externalizing behavior problems [15 ODD, 31 OD/AD, and 23 ADHD]). No baseline differences were found in cortisol between the four groups. However, the ODD and OD/AD groups showed a significantly weaker cortisol response to stress compared to the ADHD and NC groups; the ADHD group had a similar cortisol response as the NC group. Within the ODD group this pattern of low cortisol responsivity was most clearly present in the more severely affected inpatients. With respect to HR, the ODD group had a significantly lower HR during baseline and stressful conditions. The higher HR levels in the OD/AD and ADHD groups were likely to be caused by methylphenidate. The externalizing groups had significantly lower SCL levels, and no differences were found between these groups. It was concluded that differences in cortisol responsivity during stress exposure are important in distinguishing within a group of children with externalizing behavior between those with ODD and ADHD.


Correspondence:
c1 Address correspondence and reprint requests to: Heddeke Snoek, Department of Child and Adolescent Psychiatry, A01.468, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands; E-mail: h.snoek@psych.azu.nl.