British Journal of Nutrition

Short Communication

Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment

Ariënne de Jonga1, Jogchum Plata1, Dieter Lütjohanna2 and Ronald P. Mensinka1 c1

a1 Department of Human Biology, Maastricht University, Maastricht, The Netherlands

a2 Institute of Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany

Abstract

Consumption of plant sterol- or stanol-enriched margarines by statin users results in an additional LDL-cholesterol reduction of approximately 10 %, which may be larger than the average decrease of 3–7 % achieved by doubling the statin dose. However, whether this effect persists in the long term is not known. Therefore, we examined in patients already on stable statin treatment the effects of 85 weeks of plant sterol and stanol ester consumption on the serum lipoprotein profile, cholesterol metabolism, and bile acid synthesis. For this, a double-blind randomised trial was designed in which fifty-four patients consumed a control margarine with no added plant sterols or stanols for 5 weeks (run-in period). For the next 85 weeks, seventeen subjects continued with the control margarine and the other two groups with either a plant sterol (n 18) or plant stanol (n 19) (2·5 g/d each) ester-enriched margarine. Blood was sampled at the end of the run-in period and every 20 weeks during the intervention period. Compared with the control group, plant sterol and stanol ester consumption reduced LDL-cholesterol by 0·28 mmol/l (or 8·7 %; P = 0·08) and 0·42 mmol/l (13·1 %; P = 0·006) respectively after 85 weeks. No effects were found on plasma concentrations of oxysterols or 7α-hydroxy-4-cholesten-3-one, a bile acid synthesis marker. We conclude that long-term consumption of both plant sterol and stanol esters effectively lowered LDL-cholesterol concentrations in statin users.

(Received October 31 2007)

(Revised February 18 2008)

(Accepted February 21 2008)

(Online publication April 01 2008)

Correspondence:

c1 Corresponding author: Professor R. P. Mensink, fax +31 43 3670976, email r.mensink@hb.unimaas.nl

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