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The influence of sex and age on antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum in human populations in Kenya and the Philippines

Published online by Cambridge University Press:  01 April 1997

M. WEBSTER ,
B. D. L. LIBRANDA-RAMIREZ ,
G. D. ALIGUI ,
R. M. OLVEDA ,
J. H. OUMA ,
H. C. KARIUKI ,
G. KIMANI ,
G. R. OLDS ,
A. J. C. FULFORD  and
A. E. BUTTERWORTH
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M. WEBSTER
Affiliation:
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP
B. D. L. LIBRANDA-RAMIREZ
Affiliation:
Research Institute for Tropical Medicine, Alabang, Muntinlupa, Metro Manila 1770, Philippines
G. D. ALIGUI
Affiliation:
International Health Institute, Brown University, Providence, Rhode Island 02912, USA
R. M. OLVEDA
Affiliation:
Research Institute for Tropical Medicine, Alabang, Muntinlupa, Metro Manila 1770, Philippines
J. H. OUMA
Affiliation:
Division of Vector Borne Disease, P.O. Box 20750, Nairobi, Kenya
H. C. KARIUKI
Affiliation:
Division of Vector Borne Disease, P.O. Box 20750, Nairobi, Kenya
G. KIMANI
Affiliation:
Kenya Medical Research Institute, P.O. Box 54840, Nairobi, Kenya
G. R. OLDS
Affiliation:
MetroGeneral Health Medical Centre, 2500 MetroHealth Drive, Cleveland, 44109–1998, USA
A. J. C. FULFORD
Affiliation:
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP
A. E. BUTTERWORTH
Affiliation:
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP
D. W. DUNNE
Affiliation:
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP
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Abstract

We have investigated the effects of host age and sex on human antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum adult worm (AW) and soluble egg (SEA) antigens, using sera from subjects in Kenya and the Philippines. Similar trends with age were observed between the two populations despite host, parasite and environmental differences between the two geographical locations. IgE to AW increased with age, whereas most isotype responses to SEA decreased with age. IgG1, IgG3 and IgG4 subclass responses to adult worm, however, did not show a broadly rising or falling pattern with age. Males were found to have higher IgG1, IgG4 and IgE to AW in both populations. This sex difference remained significant in the Kenyan population even after controlling statistically for confounding factors such as age and differences in intensity of infection. Analysis of S. mansoni and S. japonicum adult worm antigens reactive with IgE revealed a predominant 22 kDa band in both parasites. Only those individuals with relatively high IgE titres specifically reactive with S. mansoni or S. japonicum AW had detectable IgE against Sj22 or Sm22.

Keywords

human antibody isotypesIgESchistosoma mansoniSchistosoma japonicum
Type
Research Article
Information
Parasitology , Volume 114 , Issue 4 , April 1997 , pp. 383 - 393
Copyright
© 1997 Cambridge University Press

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