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Early exposure to lead and neuropsychological outcome in adolescence

Published online by Cambridge University Press:  01 March 2004

M. DOUGLAS RIS ,
KIM N. DIETRICH ,
PAUL A. SUCCOP ,
OMER G. BERGER  and
ROBERT L. BORNSCHEIN
M. DOUGLAS RIS
Affiliation:
Department of Pediatrics and the Children's Hospital Medical Center, Cincinnati, Ohio
KIM N. DIETRICH
Affiliation:
Department of Pediatrics and the Children's Hospital Medical Center, Cincinnati, Ohio University of Cincinnati College of Medicine, Department of Environmental Health, Cincinnati, Ohio
PAUL A. SUCCOP
Affiliation:
University of Cincinnati College of Medicine, Department of Environmental Health, Cincinnati, Ohio
OMER G. BERGER
Affiliation:
Department of Pediatrics and the Children's Hospital Medical Center, Cincinnati, Ohio
ROBERT L. BORNSCHEIN
Affiliation:
University of Cincinnati College of Medicine, Department of Environmental Health, Cincinnati, Ohio
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Abstract

One hundred and ninety-five participants in the Cincinnati Lead Study were neuropsychologically evaluated in mid-adolescence. The neuropsychological measures yielded five factors labeled Memory, Learning/IQ, Attention, Visuoconstruction, and Fine-Motor. Prenatal, Average Childhood, and 78 month blood lead (PbB) levels were used in a series of multiple regression analyses. Following rigorous covariate pretesting and adjustment, a significant main effect of 78 month PbB on the Fine-Motor factor was found (p < .004). Significant interactions were also found between gender and lead exposure parameters for both Attention and Visuoconstruction indicating heightened risk in males. Finally, a trend toward significance was found for the PbB × SES interaction for Learning/IQ, consistent with previous evidence of increased educational and cognitive vulnerability for youth from more disadvantaged backgrounds. These results provide new evidence from the longest continuing prospective study of the remote effects of early lead exposure. They indicate the presence of selective neuropsychological effects in this population, and also that males and females are not uniformly affected. These results also underscore the complexity of models of neurobehavioral development, and the modest predictive power of any single determinant. (JINS, 2004, 10, 261–270.)

Keywords

LeadNeuropsychological effectsEnvironmental toxicantAdolescent outcome
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 2 , March 2004 , pp. 261 - 270
Copyright
© 2004 The International Neuropsychological Society

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References

REFERENCES

Allen, G., Buxton, R.B., Wong, E.C., & Courchesne, E. (1997). Attentional activation of the cerebellum independent of motor involvement. Science, 275, 1940–1943.CrossRefGoogle Scholar
Baghurst, P.A., McMichael, A.J., Tong, S.L., Wigg, N.R., Vimpani, G.V., & Robertson, E.F. (1995). Exposure to environmental lead and visual-motor integration at 7 years: The Port Pirie Cohort Study. Epidemiology, 6, 104–109.CrossRefGoogle Scholar
Baghurst, P.A., McMichael, A.J., Wigg, N.R., Vimpani, G.V., Robertson, E.F., Roberts, R.J., & Tong, S.L. (1992). Environmental exposure to lead and children's intelligence at the age of seven years. The Port Pirie Cohort Study. New England Journal of Medicine, 327, 1279–1284.Google Scholar
Bellinger, D., Leviton, A., Allred, E., & Rabinowitz, M. (1994). Pre- and postnatal lead exposure and behavior problems in school-aged children. Environmental Research, 66, 12–30.Google Scholar
Bellinger, D., Leviton, A., & Sloman, J. (1990). Antecedents and correlates of improved cognitive performance in children exposed in utero to low levels of lead. Environmental Health Perspectives, 89, 5–11.Google Scholar
Bellinger, D.C. (2000). Effect modification in epidemiologic studies of low-level neurotoxicant exposures and health outcomes. Neurotoxicology and Teratology, 22, 133–140.CrossRefGoogle Scholar
Bellinger, D.C., Stiles, K.M., & Needleman, H.L. (1992). Low-level lead exposure, intelligence and academic achievement: A long-term follow-up study. Pediatrics, 90, 855–861.Google Scholar
Bernstein, J.H. & Waber, D.P. (1996). Developmental scoring system for the Rey-Osterreith Complex Figure: Professional manual. Odessa, FL: Psychological Assessement Resources.
Byers, R.K., & Lord (1943). Late effects of lead poisoning on mental development follow-up reassessment. Pediatrics, 67, 911–919.Google Scholar
Canfield, R.L., Henderson, C.R., Cory-Slechta, D.A., Cox, C., Jusko, T.A., & Lanphear, B.P. (2003). Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. New England Journal of Medicine, 348, 1517–1526.CrossRefGoogle Scholar
Cory-Slechta, D.A. (1997). Relationships between Pb-induced changes in neurotransmitter system function and behavioral toxicity. Neurotoxicology, 18, 673–688.Google Scholar
Coscia, J.M., Ris, M.D., Succop, P.A., & Dietrich, K.N. (2003). Cognitive development of lead exposed children from ages 6 to 15 years: An application of growth curve analysis. Child Neuropsychology, 9, 10–21.CrossRefGoogle Scholar
Dennis, M. (1989). Language and the young damaged brain. In T. Boll and B.K. Bryant (Eds.), Clinical neuropsychology and brain function: Research, measurement, and practice (pp. 89–123). Washington, DC: American Psychological Association.
Dietrich, K.N., Berger, O.G., & Succop, P.A. (1993a). Lead exposure and the motor developmental status of urban six-year-old children in the Cincinnati Prospective Study. Pediatrics, 91, 301–307.Google Scholar
Dietrich, K.N., Berger, O.G., Succop, P.A., Hammond, P.B., & Bornschein, R.L. (1993b). The developmental consequences of low to moderate prenatal and postnatal lead exposure: Intellectual attainment in the Cincinnati Lead Study Cohort following school entry. Neurotoxicology and Teratology, 15, 37–44.Google Scholar
Dietrich, K.N., Krafft, K.M., Bornschein, R.L., Hammond, P.B., Berger, O., Succop, P.A., & Bier, M. (1987). Low-level fetal lead exposure effect on neurobehavioral development in early infancy. Pediatrics, 80, 721–730.Google Scholar
Dietrich, K.N., Ris, M.D., Succop, P.A., Berger, O.G., & Bornschein, R.L. (2001). Early exposure to lead and juvenile delinquency. Neurotoxicology and Teratology, 23, 511–518.CrossRefGoogle Scholar
Dietrich, K.N., Succop, P.A., Berger, O.G., Hammond, P.B., & Bornschein, R.L. (1991). Lead exposure and the cognitive development of urban preschool children: The Cincinnati Lead Study cohort at age 4 years. Neurotoxicology anl Teratology, 13, 203–211.Google Scholar
Dudek, B. & Merecz, D. (1997). Impairment of psychological functions in children environmentally exposed to lead. International Journal of Occupational Medicine and Environmental Health, 10, 37–46.Google Scholar
Ernhart, C.B. (1995). Inconsistencies in the lead-effects literature exist and cannot be explained by “effect modification”. Neurotoxicology and Teratology, 17, 227–233.CrossRefGoogle Scholar
Fergusson, D.M. & Horwood, L.J. (1993). The effects of lead levels on the growth of word recognition in middle childhood. International Journal of Epidemiology, 22, 891–897.CrossRefGoogle Scholar
Freedman, R., Olson, L., & Hoffer, B.J. (1990). Toxic effects of lead on neuronal development and function. Environmental Health Perspectives, 89, 27–33.CrossRefGoogle Scholar
Gibson, J.L. (1917). The diagnosis, prophylaxis, and treatment of plumbic ocular neuritis amongst Queensland children. Medical Journal of Australia, September 8, 201–204.Google Scholar
Greene, T. & Ernhart, C.B. (1991). Adjustment for cofactors in pediatric research. Journal of Developmental and Behavioral Pediatrics, 12, 378–385.Google Scholar
Greenough, W.T., Black, J.E., & Wallace, C.S. (1987). Experience and brain development. Child Development, 58, 539–559.CrossRefGoogle Scholar
Kaufman, A.S. (2001). Do low levels of lead produce IQ loss in children? A careful examination of the literature. Archives of Clinical Neuropsychology, 16, 303–341.CrossRefGoogle Scholar
Lanphear, B.P., Dietrich, K., Auinger, P., & Cox, C. (2000). Cognitive deficits associated with blood lead concentrations <10 microg/dL in US children and adolescents. Public Health Reports, 115, 521–529.CrossRefGoogle Scholar
Lasley, S.M., Green, M.C., & Gilbert, M.E. (1999). Influence of exposure period on in vivo hippocampal glutamate and GABA release in rats chronically exposed to lead. Neurotoxicology, 20, 619–629.Google Scholar
Major, R.H. (1931). Some landmarks in the history of lead poisoning. Annals of Medical History, 3, 218–227.Google Scholar
Mushak, P. (1989). Biological monitoring of lead exposure in children: Overview of selected biokinetic and toxicological issues. In M.A. Smith, L.D. Grant, & A.I. Sors (Eds.), Lead exposure and child development: An international assessment (pp. 129–145). London: Kluwer Academic Publishers.
Nation, J.R. & Gleaves, D.H. (2001). Low-level lead exposure and intelligence in children. Archives of Clinical Neuropsychology, 16, 375–388.CrossRefGoogle Scholar
Needleman, H.L., Gunnoe, C., Leviton, A., Reed, R., Peresie, H., Maher, C., & Barrett, P. (1979). Deficits in psychologic and classroom performance of children with elevated dentine lead levels. New England Journal of Medicine, 300, 689–695.Google Scholar
Needleman, H.L., Schell, A., Bellinger, D., Leviton, A., & Allred, E. (1990). The long-term effects of low doses of lead in childhood: An 11-year follow-up report. New England Journal of Medicine, 322, 83–88.CrossRefGoogle Scholar
Pedhazur, E.J. (1982). Multiple regression in behavioral research. New York: Holt.
Pocock, S.J., Ashby, D., & Smith, M.A. (1987). Lead exposure and children's intellectual performance. International Journal of Epidemiology, 16, 57–67.CrossRefGoogle Scholar
Rabinowitz, M., Wang, J.D., & Soong, W.T. (1993). Lead and classroom performance at seven primary schools in Taiwan. Research in Human Capital and Development, 7, 253–272.Google Scholar
Ris, M.D. (2003). Casual inference in lead research: Introduction to the special section on the neurobehavioral effects of environment lead. Child Neuropsychology, 9, 1–9.Google Scholar
Roda, S.M., Greenland, R.D., Bornschein, R.L., & Hammond, P.B. (1988). Anodic stripping voltammetry procedure modified for improved accuracy of blood lead analysis. Clinical Chemistry, 34, 563–567.Google Scholar
Schneider, J.S., Lee, M.H., Anderson, D.W., Zuck, L., & Lidsky, T.I. (2001). Enriched environment during development is protective against lead-induced neurotoxicity. Brain Research, 896, 48–55.CrossRefGoogle Scholar
Schwartz, J. (1994). Low-level lead exposure and children's IQ: A meta-analysis and search for a threshold. Environmental Research, 65, 42–55.CrossRefGoogle Scholar
Stiles, K.M. & Bellinger, D.C. (1993). Neuropsychological correlates of low-level lead exposure in school-age children: A prospective study. Neurotoxicology and Teratology, 15, 27–35.CrossRefGoogle Scholar
Trope, I., Lopez-Villegas, D., Cecil, K.M., & Lenkinski, R.E. (2001). Exposure to lead appears to selectively alter metabolism of cortical gray matter. Pediatrics, 107, 1437–1442.Google Scholar
US Centers for Disease Control. (1991). Preventing lead poisoning in young children–A statement by the United States Centers for Disease Control. Atlanta, GA: United States Department of Health and Human Services, Public Health Service, Center for Disease Control.
Wasserman, G.A., Facgtor-Litvak, P., Liu, X., Todd, A., Kline, J.K., Slavkovich, V., Popovac, D., & Graziano, J.H. (2003). The relationship between blood lead, bone lead and child intelligence. Child Neuropsychology, 9, 22–34.Google Scholar
Wasserman, G.A., Musabegovic, A., Liu, X., Kline, J., Factor-Litvak, P., & Graziano, J.H. (2000). Lead exposure and motor functioning in 4(1/2)-year-old children: The Yugoslavia prospective study. Journal of Pediatrics, 137, 555–561.CrossRefGoogle Scholar
Winneke, G. & Kraemer, U. (1984). Neuropsychological effects of lead in children: Interactions with social background variables. Neuropsychobiology, 11, 195–202.CrossRefGoogle Scholar
World Health Organization. (1995). Environmental Health Criteria 165: Inorganic lead. W.H.O. International Programme on Chemical Safety. Geneva: Author.