The International Journal of Neuropsychopharmacology



Revising polypharmacy to a single antipsychotic regimen for patients with chronic schizophrenia


Takefumi Suzuki a1c1, Hiroyuki Uchida a1, Kenji F. Tanaka a1, Kensuke Nomura a1, Harumasa Takano a1, Akira Tanabe a1, Koichiro Watanabe a1, Gohei Yagi a1 and Haruo Kashima a1
a1 Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

Article author query
suzuki t   [PubMed][Google Scholar] 
uchida h   [PubMed][Google Scholar] 
tanaka k   [PubMed][Google Scholar] 
nomura k   [PubMed][Google Scholar] 
takano h   [PubMed][Google Scholar] 
tanabe a   [PubMed][Google Scholar] 
watanabe k   [PubMed][Google Scholar] 
yagi g   [PubMed][Google Scholar] 
kashima h   [PubMed][Google Scholar] 

Abstract

Antipsychotic polypharmacy has been empirically used and a recent trend in favour of that mode of therapy has been suggested for the treatment of schizophrenia. The clinical efficacy, however, still remains to be clarified. In order to critically evaluate the usefulness of such kind of psychopharmacotherapy, antipsychotic combination regimen (polypharmacy) was switched to a treatment with the single main antipsychotic (monotherapy) in cross-tapered fashion, while approximately maintaining the total amount, for patients with chronic schizophrenia. Patients had been treated with an average of three antipsychotics and maintained with the same antipsychotic polypharmacy regimen for more than 6 months before the entry. They were followed up with an antipsychotic monopharmacy and evaluated at 24 wk after completion of switching. Forty-seven patients were recruited for this study. Of 44 patients for whom evaluation was possible, 24 (54.5%) remained stable, while 10 (22.7%) showed improvement and the same number of patients ended in a deleterious status. Twenty-two patients were converted to antipsychotic monotherapy, while another 12 needed minimal dosing of low-potency agents. Overall, social functioning, evaluated by the Global Assessment of Functioning and the Clinical Global Impression, remained unchanged. Eighteen of 34 successful patients showed adverse effects of the main antipsychotic medication, which necessitated a significant dose reduction. Nine out of 10 deteriorating patients had been treated with a combination of low- and high-potency antipsychotics. It is suggested that many instances of antipsychotic polypharmacy is avoidable. The result is compatible with the current treatment recommendations, which dictate the use of a single antipsychotic agent.

(Received May 11 2003)
(Reviewed July 2 2003)
(Revised August 6 2003)
(Accepted August 10 2003)


Key Words: Antipsychotics; monotherapy; polypharmacy; schizophrenia.

Correspondence:
c1 Dr T. Suzuki, Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Tel.: +81-3-5363-3829 (ext. 62453) Fax: +81-3-5379-0187 E-mail: takefumi@oak.dti.ne.jp


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