Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-23T06:24:14.959Z Has data issue: false hasContentIssue false
  • English
  • Français

Electrocardiographic characterization in Trypanosoma cruzi reinfected mice

Published online by Cambridge University Press:  16 April 2004

J. M. BUSTAMANTE ,
H. W. RIVAROLA ,
J. A. PALMA  and
P. A. PAGLINI-OLIVA
J. M. BUSTAMANTE
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, CP:5000 Córdoba, Argentina
H. W. RIVAROLA
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, CP:5000 Córdoba, Argentina
J. A. PALMA
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, CP:5000 Córdoba, Argentina
P. A. PAGLINI-OLIVA
Affiliation:
Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, CP:5000 Córdoba, Argentina
Get access Rights & Permissions [Opens in a new window]

Abstract

Chagas' disease, caused by Trypanosoma cruzi, affects approximately 20 million people. There are 3 stages in the disease: acute, intermediate and chronic, the diversity and severity of the symptoms range from a mild electrocardiographic alteration to sudden death. We have previously demonstrated that when reinfections were carried out in the acute phase they produce greater cardiac damage. The aim of the present work was to investigate whether T. cruzi reinfected mice present electrocardiographic abnormalities that could be characteristic and only achieved after reinfections. Of the mice reinfected during the acute phase 100% showed abnormalities from days 90 post-infection, with a predominance of auricle ventricle blocks (67–71%). All the mice reinfected during the chronic infection showed electrocardiographic alteration after 30 days post-first reinfection. Of the mice infected, without reinfection, 60% exhibited electrocardiographic dysfunction at 90 days post-infection. Our results demonstrated that when the host was reinfected in the acute phase, more serious electrocardiographic alterations were developed than when the reinfections were carried out in the chronic stage. Sudden death described in some chagasic patients, might be related to some of the findings described here.

Keywords

Trypanosoma cruzielectrocardiographyreinfection
Type
Research Article
Information
Parasitology , Volume 128 , Issue 4 , April 2004 , pp. 415 - 419
Copyright
© 2004 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

ANONYMOUS (1999). Recommendations from Satellite Meeting. International Symposium to Commemorate the 90th Anniversary of the Discovery of Chagas' disease. Rio de Janeiro, Brazil. Memorias do Instituto Oswaldo Cruz 94, 429–432.
ANDRADE, Z. (1999). Immunopathology of Chagas' disease. Memorias do Instituto Oswaldo Cruz 94, 71–80.CrossRefGoogle Scholar
BERUL, C. I., ARONOVITZ, M. J., WANG, P. J. & MENDELSOHN, M. E. (1996). In vivo cardiac electrophysiology studies in mouse. Circulation 94, 2641–2648.CrossRefGoogle Scholar
BRENER, Z. (1967). Algunos aspectos da imunidade adquirida em camundongos experimentalmente inoculados con Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de Sao Paulo 9, 233–238.Google Scholar
BUSTAMANTE, J. M., RIVAROLA, H. W., FERNÁNDEZ, A. R., ENDERS, E. J., FRETES, R., PALMA, J. A. & PAGLINI-OLIVA, P. A. (2002). Trypanosoma cruzi reinfections in mice determine the severity of cardiac damage. International Journal for Parasitology 32, 889–896.CrossRefGoogle Scholar
BUSTAMANTE, J. M., RIVAROLA, H. W., FERNÁNDEZ, A. R., ENDERS, J. E., FRETES, R., PALMA, J. A. & PAGLINI-OLIVA, P. A. (2003). Indeterminate Chagas' disease: Typanosoma cruzi strain and re-infection are factors involved in the progression of cardiopathy. Clinical Science 104, 415–420.CrossRefGoogle Scholar
CABRINE-SANTOS, M., SILVA, E. L., CHAPADEIRO, E. & RAMÍREZ, L. E. (2001). Trypanosoma cruzi: Characterization of reinfection and search for tissue tropism in hamsters (Mesocricetus auratus). Experimental Parasitology 99, 160–167.CrossRefGoogle Scholar
De ANDRADE, A. L., ZICKER, F., RASSI, A., RASSI, A. G., OLIVEIRA, R. M., SILVA, S. A. & TURCHI MARTELLI, C. M. (1998). Early Electrocardiographic abnormalities in Trypanosoma cruzi seropositive children. American Journal of Tropical Medicine and Hygiene 59, 530–534.CrossRefGoogle Scholar
DIAS, E. (1963). Os efeitos da superinfecçao sobre a evoluçao da cardiopatia crônica chagasica. Revista Goiana de Medicina 9, 233–239.Google Scholar
FERNÁNDEZ, A. R., ENDERS, J. E., RIVAROLA, H. W., PAGLINI, P. A. & PALMA, J. A. (1996). Cardiac β receptors' density or affinity modified by different Trypanosoma cruzi amount. Acta Physiologica Pharmcologica et Therapeutica Latinoamericana 47, 137–143.Google Scholar
LAGUENS, R. P., CABEZA MECKERT, P., BASOMBRIO, M. A., CHAMBO, M. A., COSSIO, P., ARANA, R. & GELPI, R. J. (1980). Infección crónica del ratón con Trypanosoma cruzi. Modelo experimental de enfermedad de Chagas. Medicina 40, 33.Google Scholar
LAURIA-PIRES, I. & TEIXEIRA, A. R. (1997). Superinfections with genetically characterised Trypanosoma cruzi clones did not aggravate morbidity and mortality in BALB/c mice. Journal of Parasitology 83, 819–824.CrossRefGoogle Scholar
MACEDO, V. (1976). Influencia da exposiçao à reinfeçao na evoluçao da doença de Chagas: Estudo longitudinal de cinco anos. Revista do Patologia Tropical 5, 33–116.Google Scholar
MACHADO, E. M., FERNÁNDEZ, A. J., MURTA, S. M., VITOR, R. W. A., CAMILO, Jr., J. R., PINHEIRO, S. W., REIS LOPES, E., ADAD, S. J., ROMANHA, A. J. & PINTO DIAS, J. C. (2001). A study of experimental reinfection by Trypanosoma cruzi in dogs. American Journal of Tropical Medicine and Hygiene 65, 958–965.CrossRefGoogle Scholar
MAGUIRE, J. H., HOFF, K. E., SHERLOCK, I., GUIMARAES, A. C., SLEIGH, A. C., RAMOS, N. B., MOTT, K. E. & WELLER, T. H. (1987). Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community. Circulation 75, 1140–1145.CrossRefGoogle Scholar
MONCAYO, A. (1999). Progress towards interruption of transmission of Chagas disease. Memorias do Instituto Oswaldo Cruz 94, 401–404.CrossRefGoogle Scholar
NUSSENZWEIG, V., DEANE, L. M. & KLOETZEL, K. (1963). Differences in antigenic constitution of strains of Trypanosoma cruzi. Experimental Parasitology 14, 211–232.CrossRefGoogle Scholar
PRATA, A. (2001). Clinical and epidemiological aspects of Chagas' disease. Lancet Infectious Diseases 1, 92–100.CrossRefGoogle Scholar
PRATA, A. & MACEDO, V. O. (1984). Morbidity of Chagas' heart disease. Memorias do Instituto Oswaldo Cruz 79, 93–96.CrossRefGoogle Scholar
REVELLI, S., BERRA, H., VALENTI, J., MORENO, H., BERNASCONI, M., POLI, H. & MORINI, J. (1990). Effect of reinfection on the development of rats infected with Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de Sao Paulo 32, 260–268.CrossRefGoogle Scholar
SADIGURSKY, M. & ANDRADE, S. G. (1986). Electrocardiographic changes in experimental chronic murine Chagas' disease. Brazilian Journal of Medicine and Biological Research 19, 379–388.Google Scholar
STORINO, R. & MILEI, J. (1994). Enfermedad de Chagas. Mosby, Doyma Argentina, Buenos Aires.
WEHRENS, X. H. T., KIRCHHOFF, S. & DOEVENDANS, P. A. (2000). Mouse electrocardiography: An interval of thirty years. Cardiovascular Research 45, 231–237.CrossRefGoogle Scholar
WORLD HEALTH ORGANIZATION (1991). Control of Chagas' Disease. WHO Technical Report Series 811, 1–93. WHO, Geneva.
ZICKER, F., ALMEIDA NETTO, J. C., ZICKER, E. M. S., OLIVEIRA, R. M. & SMITH, P. G. (1990). Trypanosoma cruzi infections and electrocardiographic findings among active manual workers. A population based study in central Brazil. International Journal of Epidemiology 19, 182–186.Google Scholar