Epidemiology and Infection



Systemic pneumococcal disease in Norway 1995–2001: capsular serotypes and antimicrobial resistance


M. K. PEDERSEN a1, E. A. HØIBY a1, L. O. FRØHOLM a1, V. HASSELTVEDT a1p1, G. LERMARK a1 and D. A. CAUGANT a1a2c1
a1 Division of Infectious Disease Control, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, NO-0403 Oslo, Norway
a2 Department of Oral Biology, University of Oslo, Oslo, Norway

Article author query
pedersen m   [PubMed][Google Scholar] 
hoiby e   [PubMed][Google Scholar] 
froholm l   [PubMed][Google Scholar] 
hasseltvedt v   [PubMed][Google Scholar] 
lermark g   [PubMed][Google Scholar] 
caugant d   [PubMed][Google Scholar] 

Abstract

A total of 4624 pneumococcal isolates from episodes of systemic pneumococcal disease were received at the Norwegian Institute of Public Health during the period 1995–2001. All isolates were serotyped and tested for susceptibility to benzylpenicillin, lincomycin, erythromycin, tetracycline and trimethroprim–sulphamethoxazole. The proportion of strains resistant to these antimicrobial agents remained stable at a low level, ranging from 0·1% for benzylpenicillin to 2·5% for erythromycin. The distribution of serotypes was also stable over the 7 years: serotypes 1, 4, 9, 14, 7, 6 and 23 were the most frequent, representing 70·5% of isolates. Overall, 95·8% of the isolates were of serotypes/groups included in the current 23-valent polysaccharide vaccine, 52·2% were of serotypes/groups included in the 7-valent conjugated vaccine and 85·5% were of serotypes/groups included in the 11-valent conjugated vaccine.

(Accepted September 1 2003)


Correspondence:
c1 D. A. Caugant, Division of Infectious Disease Control, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, NO-0403 Oslo, Norway.
p1 Present address: Department of Microbiology, Sykehuset Innlandet HF, NO-2629 Lillehammer, Norway.


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