Expert Reviews in Molecular Medicine

 



Review Article

Human herpesvirus 7


Stephen Dewhurst a1c1, David Skrincosky a2 and Nanette van Loon a2
a1 Department of Microbiology and Immunology, and Cancer Center, University of Rochester Medical Center, 575 Elmwood Avenue, Box 672, Rochester NY 14642 USA.
a2 Department of Microbiology and Immunology, University of Rochester Medical Center, 575 Elmwood Avenue, Box 672, Rochester NY 14642 USA.

Abstract

Human herpesvirus 7 (HHV-7) is a recently described T-lymphotropic herpesvirus, which infects almost all children by the age of three years and persists lifelong, with the shedding of infectious virus in saliva. HHV-7 is similar to human herpesvirus 6 (HHV-6) in its genetic content and in many of its biological properties, which include the ability to cause at least some cases of exanthem subitum (roseola). Despite these similarities, important differences between HHV-7 and HHV-6 exist, including the fact that HHV-7 binds to the cellular CD4 molecule and uses this protein as a necessary component of its receptor, while HHV-6 binds to a different (and unknown) receptor. Furthermore, the pathogenesis and sequelae of HHV-7 infection remain very poorly understood. This review provides a critical summary of research on HHV-7.


Key Words: human herpesvirus 7; HHV7; herpesvirus; exanthem subitum; roseola; T lymphotropic herpesvirus; virology.

Correspondence:
c1 Department of Microbiology and Immunology, and Cancer Center, University of Rochester Medical Center, 575 Elmwood Avenue, Box 672, Rochester NY 14642 USA. Tel: +1 716 275 3216; Fax: +1 716 473 2361; E-mail: stephen_dewhurst@urmc.rochester.edu