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Negative affects are parts of the addiction syndrome

Published online by Cambridge University Press:  29 July 2008

Michel Le Moal
Affiliation:
Neurocentre Magendie, Institut François Magendie, Université VictorSegalen – Bordeaux 2, 33077 Bordeaux cedex, France. lemoal@bordeaux.inserm.fr

Abstract

Decision-making is a complex activity for which emotions and affects are essential. Maladaptive choices depend on negative affects. Vulnerabilities to drug or non-drug objects depend on previous psychopathological comorbidities. Premorbid individual characteristics allow us to understand why some individuals – and not others – enter into the addiction cycle. Moreover, plasticity of reward neurocircuitry is, at least in past, responsible for these vulnerabilities leading to compulsive drug use.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2008

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References

al'Absi, M. (2007) Stress and addiction: Biological and psychological mechanisms. Academic.Google Scholar
Anthony, J. C., Warner, L. A. & Kessler, R. C. (1994) Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: Basic findings from the National Comorbidity Survey. Experimental and Clinical Psychopharmacology 2:244–68.CrossRefGoogle Scholar
Baumeister, R. F., Heatherton, T. F. & Tice, D. M. (1994) Losing control: How and why people fail at self-regulation. Academic Press.Google Scholar
Baumeister, R. F. & Vohs, K. D. (2004) Handbook of self-regulation: Research, theory, and applications. Guilford Press.Google Scholar
Bechara, A. (2005) Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective. Nature Neuroscience 8(11):1458–63.CrossRefGoogle ScholarPubMed
Bechara, A., Damasio, H. & Damasio, A. R. (2000) Emotion, decision-making, and the orbitofrontal cortex. Cerebral Cortex 10:295307.CrossRefGoogle ScholarPubMed
Bechara, A., Damasio, H., Tranel, D. & Anderson, S. W. (1998) Dissociation of working memory from decision making within the human prefrontal cortex. Journal of Neuroscience 18:428–37.CrossRefGoogle ScholarPubMed
Damasio, A. R., Grabowski, T. J., Bechara, A., Damasio, H., Ponto, L. L., Parvizi, J. & Hichwa, R. D. (2000) Subcortical and cortical brain activity during the feeling of self-generated emotions. Nature Neuroscience 3:1049–56.CrossRefGoogle ScholarPubMed
Everitt, B. J. & Wolf, M. E. (2002) Psychomotor stimulant addiction: A neural systems perspective. Journal of Neuroscience 22(9):3312–20.CrossRefGoogle ScholarPubMed
Goldstein, R. Z. & Volkow, N. D. (2002) Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry 159:1642–52.CrossRefGoogle ScholarPubMed
Goodman, A. (1990) Addiction: Definition and implications. British Journal of Addiction 85:1403–408.CrossRefGoogle ScholarPubMed
Goodman, A. (2008) Neurobiology of addiction: An integrative review. Biochemical Pharmacology 75:266322.CrossRefGoogle ScholarPubMed
Hyman, S. E. & Malenka, R. C. (2001) Addiction and the brain: The neurobiology of compulsion and its persistence. Nature Reviews Neuroscience 2:695703.CrossRefGoogle ScholarPubMed
Kahneman, D. (2003) A perspective on judgment and choice: Mapping bounded rationality. American Psychologist 58:697720.CrossRefGoogle ScholarPubMed
Kalivas, P. W. & McFarland, K. (2003) Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology 168:4456.CrossRefGoogle ScholarPubMed
Koob, G. F. & Le Moal, M. (1997) Drug abuse: Hedonic homeostatic dysregulation. Science 278(5335):5258.CrossRefGoogle ScholarPubMed
Koob, G. F. & Le Moal, M. (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24(2):97129.CrossRefGoogle ScholarPubMed
Koob, G. F. & Le Moal, M. (2005) Plasticity of reward neurocircuitry and the ‘dark side’ of drug addiction. Nature Neuroscience 8(11):1442–44.CrossRefGoogle ScholarPubMed
Koob, G. F. & Le Moal, M. (2006) Neurobiology of addiction. Elsevier Academic.Google ScholarPubMed
Koob, G. F. & Le Moal, M. (2007) Drug addiction: Pathways to the disease and pathophysiological perspectives. European Neuropsychopharmacology 17:377–93.Google Scholar
Koob, G. F. & Le Moal, M. (2008) Addiction and the brain anti-reward system. Annual Review of Psychology 59:2953.CrossRefGoogle Scholar
Piazza, P. V., Deminière, J. M., Le Moal, M. & Simon, H. (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511–13.CrossRefGoogle ScholarPubMed
Piazza, P. V. & Le Moal, M. (1996) Pathophysiological basis of vulnerability to drug abuse: Role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annual Review of Pharmacology and Toxicology 36:359–78.CrossRefGoogle ScholarPubMed
See, R. E., Fuchs, R. A., Ledford, C. C. & McLaughlin, J. (2003) Drug addiction, relapse and the amygdala. In: The amygdala in brain function: Basic and clinical approaches, ed. Shinnick-Gallagher, P., Pitkanen, A., Shekhar, A. & Cahill, L., pp. 294307. (Series title: Annals of the New York Academy of Sciences, vol. 985). New York Academy of Sciences.Google Scholar
Shaffer, H. J., LaPlante, D. A., LaBrie, R. A., Kidman, R. C., Donato, A. N. & Stanton, M. V. (2004) Toward a syndrome model of addiction: Multiple expressions, common etiology. Harvard Review of Psychiatry 12:367–74.CrossRefGoogle Scholar
Substance Abuse and Mental Heath Services Administration. (2003) Results from the 2002 National Survey on Drug Use and Health: National Findings. Rockville, MD.Google Scholar