Surveillance of severe invasive group-G streptococcal infections and molecular typing of the isolates in Japan
|T. IKEBE a1, S. MURAYAMA a2, K. SAITOH a3, S. YAMAI a4, R. SUZUKI a4, J. ISOBE a5, D. TANAKA a5, C. KATSUKAWA a6, A. TAMARU a6, A. KATAYAMA a7, Y. FUJINAGA a7, K. HOASHI a8 and H. WATANABE a1c1|
a1 Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan
a2 Department of Bacteriology, The Yamagata Prefectural Institute of Public Health, Yamagata, 990-0031, Japan
a3 Department of Bacteriology, Fukushima Prefectural Institute of Public Health, Fukushima, 960-8560, Japan
a4 Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory, Yokohama, 241-0815, Japan
a5 Department of Bacteriology, Toyama Institute of Health, Toyama, 939-0363, Japan
a6 Department of Microbiology, Osaka Prefectural Institute of Public Health, Osaka, 537-0025, Japan
a7 Division of Biological Medicine, Yamaguchi Prefectural Research Institute of Public Health, Yamaguchi, 753-0821, Japan
a8 Department of Bacteriology, The Oita Prefectural Institute of Health and Environment, Oita, 870-1117, Japan
The number of patients with severe invasive group-G streptococcal (Streptococcus
dysgalactiae subsp. equisimilis) infections has been increasing in Japan. The emm genotypes and SmaI-digested pulsed-field gel electrophoresis DNA profiles were variable among the strains isolated, suggesting there has not been clonal expansion of a specific subpopulation of strains. However, all strains carried scpA, ska, slo and sag genes, some of which may be involved in the pathogenesis of the disease.
(Accepted July 1 2003)
c1 Dr H. Watanabe, National Institute of Infectious Diseases, Department of Bacteriology, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162-8640, Japan.