Critical molecular abnormalities in high-grade serous carcinoma of the ovary

Volume 10
Add to Basket £30.00 / $45.00
Request Permissions
Cited by Articles (CrossRef)
Cited by Articles (Google Scholar)
Citation Alert
Go to Next Abstract in TOC
Go to Previous Abstract in TOC
Blog this Article close

Copy and paste this code to insert a reference to this article in your blog or online community profile:

Highlight All
<div style="background: #FFFFFF; margin: 10px 10px 10px 10px; padding: 10px 10px 10px 20px; text-align: left; border-top: 1px dashed #a5bbd1; border-left: 10px solid #a5bbd1; font-family: Verdana, Geneva, sans-serif;"><br> <div style="font-size: 12px; padding: 0px 0px 10px 0px; font-weight:bold; color: #003366;">Critical molecular abnormalities in high-grade serous carcinoma of the ovary</div><br><div style="font-size: 10px;"><b>Martin Köbel,David Huntsman and C. Blake Gilks (2008).</b><br /> <a href="http://journals.cambridge.org/action/displayJournal?jid=ERM">Expert Reviews in Molecular Medicine</a>, <a href="http://journals.cambridge.org/action/displayJournal?jid=ERM&volumeId=10&bVolume=y#loc10 ">Volume 10</a>, December 2008 e22 <br/> <a href="http://journals.cambridge.org/action/displayAbstract?aid=1966164">http://journals.cambridge.org/action/displayAbstract?aid=1966164</a></div></div>
The code will display like this:

Critical molecular abnormalities in high-grade serous carcinoma of the ovary

Martin Köbel, David Huntsman and C. Blake Gilks (2008).
Expert Reviews in Molecular Medicine, Volume 10, December 2008 e22 http://journals.cambridge.org/action/displayAbstract?aid=1966164

Blog this Article

Expert Reviews in Molecular Medicine (2008), 10 : e22 Cambridge University Press

doi:10.1017/S146239940800077X (About doi)

Published online by Cambridge University Press 01 Aug 2008

Social Bookmarking

Cambridge Journals Online - CUP Full-Text Page

Expert Reviews in Molecular Medicine (2008), 10:e22 Cambridge University Press

doi:10.1017/S146239940800077X

Review Article

Critical molecular abnormalities in high-grade serous carcinoma of the ovary

Martin Köbel^a1^a2, David Huntsman^a1 and C. Blake Gilks^a1 ^c1

^a1Genetic Pathology Evaluation Centre of the Prostate Research Centre, Department of Pathology, Vancouver General Hospital and British Columbia Cancer Agency, Vancouver BC, Canada.

^a2Institute of Pathology, Charité Hospital, Berlin 10117, Germany.

Article author query

köbel m

huntsman d

gilks cb

Abstract

Ovarian carcinomas show more morphological heterogeneity than adenocarcinomas of any other body site. It has recently become clear that the morphologically defined subtypes of ovarian carcinoma are distinct diseases, with different risk factors, molecular events during oncogenesis, likelihood of spread, responses to chemotherapy, and outcomes. This review focuses on molecular abnormalities (in genes expressing BRCA1/2, TP53 and RB1/CCND1/CDKN2A/E2F) found in high-grade serous carcinomas of the ovary, which account for most ovarian cancer deaths. These highly aggressive but chemosensitive tumours are associated with perturbation of molecular pathways leading to genomic instability and extreme mutability and present unique challenges in oncological research and practice.

Correspondence:

^c1 Corresponding author: C. Blake Gilks, Department of Pathology, Room 1207 1^st floor JPPN, Vancouver General Hospital, 855 West 12th Ave, Vancouver, BC, Canada, V5Z 1M9. Tel.: +1 (604) 875 4901; Fax: +1 (604) 875 4797; E-mail: Blake.Gilks@vch.ca

Username or Email Address	Password