British Journal of Nutrition

Table of Contents - 2008 - Volume 100, Issue 02  

Full Papers

A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects

Andrew Abdel-Sayeda1, Christophe Binnerta1, Kim-Anne Lêa1, Murielle Bortolottia1, Philippe Schneitera1 and Luc Tappya1 c1

a1 Department of Physiology, School of Biology and Medicine, University of Lausanne, 7 rue du Bugnon, Lausanne CH-1005, Switzerland

Abstract

The effects of a 7 d high-fructose diet (HFrD) or control diet on lipid metabolism were studied in a group of six healthy lean males. Plasma NEFA and β-hydroxybutyrate concentrations, net lipid oxidation (indirect calorimetry) and exogenous lipid oxidation (13CO2 production) were monitored in basal conditions, after lipid loading (olive oil labelled with [13C]triolein) and during a standardised mental stress. Lactate clearance and the metabolic effects of an exogenous lactate infusion were also monitored. The HFrD lowered plasma concentrations of NEFA and β-hydroxybutyrate as well as lipid oxidation in both basal and after lipid-loading conditions. In addition, the HFrD blunted the increase in plasma NEFA and exogenous lipid oxidation during mental stress. The HFrD also increased basal lactate concentrations by 31·8 %, and lactate production by 53·8 %, while lactate clearance remained unchanged. Lactate infusion lowered plasma NEFA with the control diet, and net lipid oxidation with both the HFrD and control diet. These results indicate that a 7 d HFrD markedly inhibits lipolysis and lipid oxidation. The HFrD also increases lactate production, and the ensuing increased lactate utilisation may contribute to suppress lipid oxidation.

(Received July 19 2007)

(Revised November 21 2007)

(Accepted November 21 2007)

(Online publication January 21 2008)

Key Words:

Correspondence:

c1 Corresponding author: Professor Luc Tappy, fax +41 21 692 55 95, email Luc.Tappy@unil.ch

Footnotes

Abbreviations: HFrD, high-fructose diet.

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