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Advances in the sequencing of the genome of the adenophorean nematode Trichinella spiralis

Published online by Cambridge University Press:  04 July 2008

M. Mitreva  and
D. P. Jasmer
M. Mitreva*
Affiliation:
Genome Sequencing Center, Department of Genetics, Washington University School of Medicine, St Louis, MO 63108, USA
D. P. Jasmer
Affiliation:
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7040, USA
*
*Corresponding author: Genome Sequencing Center, Department of Genetics, Washington University School of Medicine, St Louis, MO 63108, USA. Tel: 001 314 286 2005. Fax: 001 314 286 1810. E-mail: mmitreva@watson.wustl.edu
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Summary

The adenophorean nematodes are evolutionarily distant from other species in the phylum Nematoda. Interspecific comparisons of predicted proteins have supported such an ancient divergence. Accordingly, Trichinella spiralis represents a basal nematode representative for genome sequencing focused on gaining a deeper insight into the evolutionary biology of nematodes. In addition, molecular characteristics that are conserved across the phylum could be of great value for control strategies with broad application. In this review, we describe and summarize progress that has been made on the sequencing and analysis of the T. spiralis genome. The genome sequence was used in preliminary analyses for the investigation of specific questions relating to the biology of T. spiralis and, more generally, to parasitic nematodes. For instance, we evaluated an unusually large DNase II-like protein family, predicted proteins of prospective interest in the parasite-host muscle cell interaction, anthelmintic targets and prospective intestinal genes, the encoded proteins (potentially) linked to immunological control against other nematodes. The results are discussed in relation to characteristics that are broadly conserved among evolutionary distant nematodes. The results lead to expectations that this genome sequence will contribute to advances in research on T. spiralis and other parasitic nematodes.

Keywords

Trichinella spiralisexpressed sequence tagsESTsgenomesequencingintestinehost-parasite interactions
Type
Review Article
Information
Parasitology , Volume 135 , Issue 8 , July 2008 , pp. 869 - 880
Copyright
Copyright © 2008 Cambridge University Press

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