Behavioral and Brain Sciences

Open Peer Commentary

Is this conjectural phenotypic dichotomy a plausible outcome of genomic imprinting?

Benjamin James Alexander Dickinsa1, David William Dickinsa2 and Thomas Edmund Dickinsa3

a1 505 Wartik Laboratory, Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, PA 16802

a2 School of Psychology, University of Liverpool, ERB, Liverpool L69 7ZA, United Kingdom

a3 School of Psychology, University of East London, London E15 4LZ, United Kingdom, and Centre for Philosophy of Natural and Social Science, The London School of Economics, London WC2A 2AE, United Kingdom.


What is the status of the dichotomy proposed and the nosological validity of the contrasting pathologies described in the target article? How plausibly can dysregulated imprinting explain the array of features described, compared with other genetic models? We believe that considering alternative models is more likely to lead in the long term to the correct classification and explanation of the component behaviours.