a1 Eunice Kennedy Shriver Center, University of Massachusetts Medical School (UMMS), Waltham, MA 02452, and Psychobiology Program, Harvard Medical School, Boston, MA 02115
a2 Neuroregeneration Laboratories, McLean Hospital, Mailman Research Center, Belmont, MA 02478
a3 Eunice Kennedy Shriver Center, University of Massachusetts Medical School (UMMS) MRDDRC, Office of the Director, Waltham, MA 02452. firstname.lastname@example.org email@example.com firstname.lastname@example.org
The confounding effects of heterogeneity in biological psychiatry and psychiatric genetics have been widely discussed in the literature. We suggest an approach in which heterogeneity may be put to use in hypothesis testing, and may find application in evaluation of the Crespi & Badcock (C&B) imprinting hypothesis. Here we consider three potential sources of etiologic subtypes for analysis.