Epidemiology and Infection

Table of Contents - 2003 - Volume 131, Issue 03  


Prognostic factors for the long-term development of ocular lesions in 327 children with congenital toxoplasmosis

C. BINQUET a1c1, M. WALLON a2, C. QUANTIN a1, L. KODJIKIAN a3, J. GARWEG a4, J. FLEURY a3, F. PEYRON a2 and M. ABRAHAMOWICZ a5
a1 Laboratoire de Biostatistique, INSERM EPI 01-06, Faculté de Médecine, 7 bd Jeanne d'Arc, 21000 Dijon, France
a2 Service de Parasitologie, Hôpital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004 Lyon, France
a3 Service d'Ophtalmologie, Hôpital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004 Lyon, France
a4 Department of Ophthalmology, University of Bern, Inselspital, CH 3010 Bern, Switzerland
a5 Department of Epidemiology and Biostatistics, McGill University, Division of Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3A 1A2

Article author query
binquet c   [PubMed][Google Scholar] 
wallon m   [PubMed][Google Scholar] 
quantin c   [PubMed][Google Scholar] 
kodjikian l   [PubMed][Google Scholar] 
garweg j   [PubMed][Google Scholar] 
fleury j   [PubMed][Google Scholar] 
peyron f   [PubMed][Google Scholar] 
abrahamowicz m   [PubMed][Google Scholar] 

Abstract

The aim of this study was to identify the high-risk factors associated with the development of ocular lesions in a large cohort of children with congenital toxoplasmosis (CT), irrespective of their gestational age at the time of maternal infection. Children were managed according to a standardized protocol and monitored for up to 14 years at the Croix-Rousse Hospital, Lyon, France. Cox model and a flexible regression, spline-based method were used for the analysis. During a median follow-up time of 6 years, 79 of the 327 children (24%) had at least one retinochoroidal lesion. No bilateral impairment of visual acuity was observed. The risk of a child developing ocular disease was higher not only when mothers were infected early during pregnancy, which was expected, but also when CT was diagnosed prior to or at the time of birth, when non-ocular manifestations were present at baseline and when birth was premature.

(Accepted July 7 2003)


Correspondence:
c1 Dr C. Binquet, Laboratoire de Biostatistique/INSERM EPI 01-06, Faculté de Médecine, 7 bd Jeanne d'Arc, 21000 Dijon, France.

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