Human herpesvirus-8 antibodies and DNA in HIV-1 infected patients in South Africa
HIV-infected individuals with high levels of IgG antibodies against human herpesvirus-8 (HHV-8) are at increased risk of developing Kaposi's sarcoma. The aim of this study was to measure the association between HHV-8 viraemia and IgG antibody responses (by immunofluorescence) in a group of 201 HIV-infected individuals attending outpatient clinics, 91 in-patients with AIDS and 87 HIV-infected patients admitted with Kaposi's sarcoma. Compared to HIV-infected outpatients, the adjusted odds ratio in relation to Kaposi's sarcoma was 15·4 (95% CI 4·4–54·2) in those with viraemia, 25·1 (95% CI 6·6–95·6) in those with a positive immunofluorescent signal and [infty infinity] (lower exact CI 33·6) in those with a high immunofluorescent signal (all P trend <0·001). Among those without HHV-8 viraemia, 23% were IgG-positive, but only 5·5% had a high immunofluorescent signal. In those who were viraemic, 89·1% were IgG-positive, and 28·2% had a high immunofluorescent signal, suggesting viraemia is associated with high HHV-8 immunofluorescence IgG signal.(Accepted June 23 2003)
c1 Dr F. Sitas, Cancer Research and Registers Division, The Cancer Council NSW, PO Box 572, Kings Cross, Sydney, NSW 2011, Australia.