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Serum leptin levels in patients with nasal polyposis

Published online by Cambridge University Press:  12 July 2007

M Guven ,
Y Bulut ,
I Aladag ,
K Yelken  and
H Erdoğan
M Guven*
Affiliation:
Department of ORL, Gaziosmanpaşa University, Tokat, Turkey
Y Bulut
Affiliation:
Department of Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
I Aladag
Affiliation:
Department of ORL, Gaziosmanpaşa University, Tokat, Turkey
K Yelken
Affiliation:
Department of ORL, Gaziosmanpaşa University, Tokat, Turkey
H Erdoğan
Affiliation:
Department of Physiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
*
Address for correspondence: Dr Mehmet Guven, Gaziosmanpasa University Medical Faculty, Department of Otorhinolaryngology, 60100 Tokat, Turkey. Fax: +9 0356213 31 79 E-mail: guvenmehmet28@yahoo.com
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Abstract

Background:

Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. The aetiopathogenetic mechanisms of nasal polyp formation are still unclear.

Objectives:

The aim of this study was to investigate the serum leptin levels in patients with nasal polyposis.

Design:

A randomised, prospective study was performed of 28 adult patients with nasal polyposis and 22 control subjects of a similar age, sex and body mass index.

Results:

Serum leptin levels were 12.10 ± 9.39 ng/ml in the nasal polyposis patients and 6.17 ± 7.68 ng/ml in the controls. A significant difference (p = 0.021) was observed in the mean serum leptin levels between nasal polyposis patients and controls.

Conclusion:

Serum leptin levels were found to be significantly higher in patients with nasal polyposis. Leptin, apart from its primary role in the regulation of body weight and energy expenditure, may have a role in the inflammatory response of nasal polyposis.

Keywords

Nasal PolypsLeptinCytokines
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 6 , June 2008 , pp. 590 - 592
Copyright
Copyright © JLO (1984) Limited 2007

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References

1 Johansonn, L, Akerlund, A, Holmberg, K, Melen, I, Bende, M. Prevalence of nasal polyps in adults: the Skovde population-based study. Ann Otol Rhinol Laryngol 2003;112:625–9Google Scholar
2 Settipane, GA. Epidemiology of nasal polyps. Allergy Asthma Proc 1996;17:231–6CrossRefGoogle ScholarPubMed
3 Bernstein, JM. The molecular biology of nasal polyposis. Curr Allergy Asthma Rep 2001;1:262–7CrossRefGoogle ScholarPubMed
4 Camplified, LA, Smith, FJ, Guisez, Y, Devos, R, Burn, P. Recombinant mouse Ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546–9Google Scholar
5 Flier, JS. Leptin expression and action: new experimental paradigm. Proc Natl Acad Sci U S A 1997;94:4242–5Google Scholar
6 Masuzaki, H, Ogawa, Y, Sagawa, N, Hosoda, K, Matsumoto, T, Mise, H et al. . Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997;3:1029–33Google Scholar
7 Loffreda, S, Yang, SQ, Lin, HZ, Karp, CL, Brengman, ML, Wang, DJ et al. Leptin regulates pro-inflammatory immune responses. FASEB J 1998;12:57–65Google Scholar
8 Matarese, G, La Cava, A, Sanna, V, Lord, GM, Lechler, RI, Fontana, S et al. Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol 2002;23:182–7CrossRefGoogle ScholarPubMed
9 Mai, X-M, Böttcher, MF, Leijon, I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 2004;15:523–30Google Scholar
10 Visser, M, Bouter, LM, McOuillan, GM, Wener, MH, Harris, TB. Eleveted C-reactive protein levels in over-weight and obese adults. JAMA 1999;282:2131–5CrossRefGoogle Scholar
11 Ünal, M, Eskandari, G, Muşlu, N, Pata, YS, Akbaş, Y. Serum leptin levels in patients with allergic rhinitis. Otolaryngol Head Neck Surg 2006;134:331–3CrossRefGoogle ScholarPubMed
12 Güler, N, Kirerleri, E, Ones, U, Tamay, Z, Salmayenli, N, Darendeliler, F. Leptin: does it have any role in childhood asthma?. J Allergy Clin Immunol 2004;114:254–9Google Scholar
13 Faggioni, R, Feingold, KR, Grunfeld, C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001;14:2565–71CrossRefGoogle Scholar
14 Sanna, V, Di Giacomo, A, La Cava, A, Lechler, RI, Fontana, S, Zappacosta, S et al. Leptin surge precedes onset of auto-immune encephalomyelitis and correlates with development of pathogenetic T cell responses. J Clin Invest 2003;111:241–50CrossRefGoogle Scholar
15 Otero, M, Lago, R, Lago, F, Casanueva, FF, Dieguez, C, Gomez-Reino, JJ et al. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 2005;579:295–301CrossRefGoogle ScholarPubMed
16 Faggioni, R, Fantuzzi, G, Gabay, C, Moser, A, Dinarello, CA, Feingold, KR et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 1999;276:136–42Google ScholarPubMed
17 Bastard, JP, Jardel, C, Delattre, J, Hainque, B, Bruckert, E, Oberlin, F. Evidence for a link between adipose tissue interleukin-6 content and serum C-reactive protein concentrations in obese subjects. Circulation 1999;99:2221–2Google Scholar
18 Raso, GM, Pacilio, M, Esposito, E, Coppola, A, Di Carlo, M, Meli, R. Leptin potentiates IFN-γ induced expression of nitric oxide synthase and cyclooxygenase-2 in murine macrophage J774A.1. Br J Pharmacol 2002;137:799–804CrossRefGoogle Scholar