The Journal of Laryngology & Otology

Main Article

Serum leptin levels in patients with nasal polyposis

M Guvena1 c1, Y Buluta2, I Aladaga1, K Yelkena1 and H Erdoğana3

a1 Department of ORL, Gaziosmanpaşa University, Tokat, Turkey

a2 Department of Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey

a3 Department of Physiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey


Background: Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. The aetiopathogenetic mechanisms of nasal polyp formation are still unclear.

Objectives: The aim of this study was to investigate the serum leptin levels in patients with nasal polyposis.

Design: A randomised, prospective study was performed of 28 adult patients with nasal polyposis and 22 control subjects of a similar age, sex and body mass index.

Results: Serum leptin levels were 12.10 ± 9.39 ng/ml in the nasal polyposis patients and 6.17 ± 7.68 ng/ml in the controls. A significant difference (p = 0.021) was observed in the mean serum leptin levels between nasal polyposis patients and controls.

Conclusion: Serum leptin levels were found to be significantly higher in patients with nasal polyposis. Leptin, apart from its primary role in the regulation of body weight and energy expenditure, may have a role in the inflammatory response of nasal polyposis.

(Accepted April 23 2007)

(Online publication July 12 2007)


c1 Address for correspondence: Dr Mehmet Guven, Gaziosmanpasa University Medical Faculty, Department of Otorhinolaryngology, 60100 Tokat, Turkey. Fax: +9 0356213 31 79 E-mail:


Dr M Guven takes responsibility for the integrity of the content of the paper.

Competing interests: None declared