Neuron Glia Biology

Research Article

Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1

Ye Hea1a2, Juan Sandovala1 and Patrizia Casaccia-Bonnefila1a2 c1

a1 Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, USA

a2 Graduate Program in Microbiology and Immunology, Robert Wood Johnson Medical School, USA

Abstract

The complexity of the adult brain is the result of an integrated series of developmental events that depends on appropriate timing of differentiation. The importance of transcriptional regulatory networks and epigenetic mechanisms of regulation of gene expression is becoming increasingly evident. Among these mechanisms, previous work has revealed the importance of histone deacetylation in oligodendrocyte differentiation. In this manuscript we define the region of interaction between transcription factor Yin-Yang 1 (YY1) and histone deacetylase 1, and characterize the functional consequences of YY1 overexpression on the differentiation of oligodendrocyte progenitors.

(Received December 18 2007)

(Revised February 12 2008)

(Accepted February 20 2008)

Correspondence:

c1 Correspondence should be addressed to Dr Patrizia Casaccia-Bonnefil, Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, UMDNJ, 675 Hoes Lane, Piscataway, NJ 08854, USA phone: +1 732 235 4520 fax: +1 732 235 4029 email: casaccpa@umdnj.edu