CJO - Abstract - Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation : longitudinal analyses in middle-aged men

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    Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation : longitudinal analyses in middle-aged men
    Helena Petersson, Samar Basu, Tommy Cederholm and Ulf Risérus (2008).
    British Journal of Nutrition, Volume 99, Issue 06, June 2008 pp 1186-1189 http://journals.cambridge.org/action/displayAbstract?aid=1850400

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British Journal of Nutrition (2008), 99 : 1186-1189 Cambridge University Press
doi:10.1017/S0007114507871674 (About doi)
Published online by Cambridge University Press 06 Dec 2007
 
Cambridge Journals Online - CUP Full-Text Page
British Journal of Nutrition (2008), 99:1186-1189 Cambridge University Press
Copyright © The Authors 2007
doi:10.1017/S0007114507871674

Short Communication

Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation : longitudinal analyses in middle-aged men

Helena Peterssona1, Samar Basua1, Tommy Cederholma1 and Ulf Risérusa1 c1

a1 Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 751 85 Uppsala, Sweden
Article author query
petersson h PubMed  Google Scholar
basu s PubMed  Google Scholar
cederholm t PubMed  Google Scholar
risérus u PubMed  Google Scholar

Abstract

Altered fatty acid (FA) composition is related to insulin resistance and CVD. One possible mediator may be inflammation, but longitudinal data relating FA composition to inflammation taking insulin resistance into account are limited. We investigated the long-term association between FA composition and C-reactive protein (CRP) concentrations in a large population-based cohort study in 767 men followed for 20 years. The association between FA composition in serum cholesteryl esters at age 50 and CRP concentrations at age 70 was investigated using linear regression. In addition, desaturase activities (stearoyl-CoA desaturase-1 (SCD-1), Δ5- and Δ6-desaturase) were estimated using FA product-to-precursor ratios. Insulin resistance was measured directly at follow-up by euglycaemic clamp. After adjusting for confounders (smoking, physical activity, alcohol intake, obesity and erythrocyte sedimentation rate) CRP concentrations were inversely associated with the proportion of 18 : 2n-6 (P = 0·002) and positively associated with 16 : 1n-7 (P = 0·008), 18 : 1n-9 (P = 0·0003), 20 : 5n-3 (P = 0·04) and estimated SCD-1 (P = 0·005) and Δ6-desaturase (P = 0·02) activities. After adding insulin resistance to the model, 18 : 1n-9, 18 : 2n-6 and SCD-1 remained significant predictors of CRP. A FA composition indicating low intake of 18 : 2n-6, high intake of SFA and high SCD-1 activity is, in a Swedish population of middle-aged men, associated with CRP concentrations 20 years later, even independently of obesity and insulin resistance.

(Received August 16 2007)

(Revised October 22 2007)

(Accepted October 25 2007)

(Online publication December 06 2007)

Key Words:C-reactive protein; Fatty acids; SCD-1; Inflammation

Correspondence:

c1 Corresponding author: Dr Ulf Risérus, fax +46 18 6117976, email ulf.riserus@pubcare.uu.se

Footnotes

Abbreviations: CE, cholesteryl esters; CRP, C-reactive protein; FA, fatty acid; HOMA-IR, homeostasis model assessment of insulin resistance index; SCD-1, stearoyl-CoA desaturase-1

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