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Neuron Specific Enolase (NSE): A Valuable Prognostic Factor of Central Nervous System Dysfunction Following Cardiac Surgery

Published online by Cambridge University Press:  01 February 2008

E.A. Konstantinou ,
K. Venetsanou ,
A.P. Mitsos ,
K.V. Mamoura ,
E.E. Theodosopoulou ,
T. Fotis  and
G. Baltopoulos
E.A. Konstantinou*
Affiliation:
Evgenidion University Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece
K. Venetsanou
Affiliation:
Evgenidion University Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece
A.P. Mitsos
Affiliation:
Evgenidion University Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece
K.V. Mamoura
Affiliation:
Evgenidion University Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece
E.E. Theodosopoulou
Affiliation:
Evgenidion University Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece
T. Fotis
Affiliation:
Evgenidion University Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece
G. Baltopoulos
Affiliation:
Evgenidion University Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece
*
Correspondence to. Evangelos A. Konstantinou, 18 Kivelis Street, 15238, Halandri, Athens, Greece. E-mail: ekonstan30@yahoo.com
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Abstract

Purpose

The aim of this study was to evaluate neuron specific enolase (NSE) as prognostic factor for CNS disorders developed in relation to cardiac surgery.

Patients and methods

A cohort of 92 patients were divided into two groups; the experimental group consisted of patients undergoing open-heart bypass surgery (50 patients) and the control group consisting of 42 patients undergoing general surgery procedures. The blood levels of NSE were measured in both groups before and 24 h after the operation and have been related to the incidence of the postoperative brain damage as well as to the duration of the extracorporeal circulation (ECC).

Results

The analysis of our results showed that the changes of blood NSE levels, before and immediately after ECC in open-heart surgery have been related to the incidence of postoperative brain dysfunction according to a specific mathematical equation. This incidence was raised also in relation to the age of the patient and the duration of ECC. On the contrary, NSE seems to have no prognostic value in general surgery.

Conclusion

NSE can be used in cardiac surgery as a simple and reliable prognostic factor to predict postoperative brain dysfunction.

Keywords

Neuron specific enolase (NSE)prognosispostoperative CNS disorderscardiac surgery
Type
Original Article
Information
British Journal of Anaesthetic & Recovery Nursing , Volume 9 , Issue 1 , February 2008 , pp. 22 - 28
Copyright
Copyright © British Association of Anaesthetic and Recovery Nursing 2008

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