Genetical Research

Research Article

Interactions of selection, linkage and drift in the dynamics of polygenic characters

Frédéric Hospitala1 c1 and Claude Chevaleta2

a1 Station de Génétique Végétale, INRA/UPS/INA-PG, Ferme du Moulon, 91190 Gif sur Yvette, France

a2 Laboratoire de Génétique Cellulaire, INRA, BP27, 31326 Castanet Tolosan Cedex, France

Summary

We study the dynamics under directional truncation selection of the genetic variability of a quantitative character controlled by a finite number of possibly linked loci with additive effects. After the first generation of selection, the build-up of linkage disequilibria (Bulmer effect) is analytically demonstrated from a genetical point of view in an infinite population. In the following generations, the dynamics of the system in a finite population are predicted using analytic recurrences under a multi-normal approximation, and computer simulations. The effects of recombination on the dynamics of linkage disequilibria induced by selection and drift, and the consequences for the additive genetic variance are then analysed and discussed from the simulation results. Compared to the rapid exploitation of genetic variability promoted by high recombination rates, low recombination rates promote an early storage of genetic variability in repulsion associations of alleles and a possible late release of genetic variance in the population, so that the variability of the character may be maintained over a longer period of time. In some cases, favourable recombination events in tightly linked systems induce an increase of the additive variance of the character, which may explain some results observed in long-term selection experiments. Our results emphasize that the joint effects of selection, linkage and drift must notbe neglected in theoretical quantitative genetics, and require further investigation.

(Received November 11 1994)

(Revised July 15 1995)

Correspondence:

c1 Frédéric Hospital, Station de Génétique Vététale, INRA/UPS/INA-PG, Ferme du Moulon, 91190 Gif sur Yvette, France. Phone: (33) (1) 69 33 23 36; Fax: (33) (1) 69 33 23 40; E-mail: fred@moulon.inra.fr.

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