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Effect of sperm genotype on chromatid segregation in female mice heterozygous for aberrant chromosome 1

Published online by Cambridge University Press:  14 April 2009

Sergei I. Agulnik ,
Igor D. Sabantsev  and
Anatoly O. Ruvinsky
Sergei I. Agulnik
Affiliation:
Institute of Cytology and Genetics, Siberian Department of Academy of Sciences of Russia, Novosibirsk 630090Russia
Igor D. Sabantsev
Affiliation:
Institute of Cytology and Genetics, Siberian Department of Academy of Sciences of Russia, Novosibirsk 630090Russia
Anatoly O. Ruvinsky*
Affiliation:
Institute of Cytology and Genetics, Siberian Department of Academy of Sciences of Russia, Novosibirsk 630090Russia
*
*Corresponding author.
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Summary

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An aberrant chromosome 1 with two large homogeneously staining insertions was isolated from wild populations of Mus musculus musculus. The specific features of the aberrant chromosome have been described elsewhere (Agulnik et al. 1990). These include its preferential entry into the oocyte of heterozygous females, increased mortality of homozygotes and decreased fertility of homozygous females. Here we present data indicating that chromatid segregation in heterozygous females depends upon which sperm enters the oocyte before the second meiotic division: meioticdrive is powerful when it is sperm bearing normal chromosome 1, and segregation normalizesduring Mil when it is sperm bearing chromosome 1 with the extra segment. Experimental data are adduced and explanations offered for the observed phenomenon.

Type
Research Article
Information
Genetics Research , Volume 61 , Issue 2 , April 1993 , pp. 97 - 100
Copyright
Copyright © Cambridge University Press 1993

References

Agulnik, S., Gorlov, I. & Agulnik, A. (1988). New variant of chromosome 1 in the house mouse Mus musculus. Citologija 30, 773–776 (in Russian).Google Scholar
Agulnik, S. I., Agulnik, A. I. & Ruvinsky, A. O. (1990 a). Meiotic drive in female mice heterozygous for the HSR insertions on chromosome 1. Genetical Research 55, 97–100.CrossRefGoogle ScholarPubMed
Agulnik, S. I., Borodin, P. M., Gorlov, I. P., Ladygina, T. Yu. & Pak, S. D. (1990 b). The origin of a double insertion of homogeneously staining regions in the house mouse (Mus musculus musculus). Heredity 65, 265–267.CrossRefGoogle ScholarPubMed
Agulnik, S., Sabantsev, I. D., Orlova, G. V. & Ruvinsky, A. O. (1993). Meiotic drive on aberrant chromosome 1 in the mouse is determinated by a linked distorter. Genetical Research 61, 91–96.CrossRefGoogle ScholarPubMed
Baker, B. S., Carpenter, A. T. C., Esposito, M. S., et al. (1976). The genetic control of meiosis. Annual Review of Genetics 10, 53–134.CrossRefGoogle ScholarPubMed
Dyban, A. P. & Baranov, V. S. (1978). Methods. In Cytogenetics of Mammalian Development, pp. 216–218. Moscow: Nauka (in Russian).Google Scholar
Golubovskaya, I. N. (1979). Genetic control of meiosis. International Review of Cytology 58, 247–290.CrossRefGoogle ScholarPubMed
Maro, B., Howlett, S. K., Johnson, M. H. (1986). Cellular and molecular interpretation of early development. The first cell cycle. In Gametogenesis and the Early Embryo, pp. 389–407. Alan R. Liss Inc.Google Scholar
Traut, W., Winking, H. & Adolph, S. (1984). An extra segment in chromosome 1 of wild Mus musculus: a Cband positive homogeneously staining region. Cytogenetics and Cell Genetics 38, 290–297.CrossRefGoogle ScholarPubMed
Weith, A., Winking, H., Brackmann, B., Boldyreff, B. & Traut, W. (1987). Microclones from a germ line HSR detect amplification and complex rearrangements of DNA sequences. EMBO Journal 6, 1295–1300.CrossRefGoogle ScholarPubMed