Genetical Research

Research Article

Further evidence for the importance of parental source of the Xce allele in X chromosome inactivation

Deborah J. Fowlisa1 p1, John D. Ansella1 c1 and H. Spedding Micklema1

a1 Department of Zoology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT


Using mice that were mosaics for both Xce and phosphoglycerate kinase (Pgk-1) alleles, we present further evidence that the parental source of the X chromosome may affect the probability of that X chromosome remaining active. The reciprocal cross differences in PGK-1 activity described here are intermediate between those published previously for other alleles of Xce.

(Received September 24 1990)

(Revised January 25 1991)


c1 Corresponding author.

p1 Current address: Duncan Guthrie Institute of Medical Genetics, Yorkhill Hospital, Yorkhill, Glasgow G38SJ.