Genetical Research

Table of Contents - 1983 - Volume 41, Issue 01  

Research Article

X-chromosome segregation, maternal age and aneuploidy in the XO mouse

J. D. Brooka1

a1 MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU

Abstract

Cytogenetic studies have ascertained that the segregation of the X-chromosome, during the first meiotic division of the oocyte in XO mice, occurs at random, contrary to the finding of some earlier authors. The ratio of nullo-X to X-bearing oocytes at ovulation does not change with maternal age. The usefulness of the XO mouse as a model for aneuploidy production in women (Lyon & Hawker, 1973) is discussed.

(Received August 26 1982)

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