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Lethality of heterozygotes between t-haplotype complementation groups of mouse: sex-related effect on lethality of t6/tw5 heterozygotes

Published online by Cambridge University Press:  14 April 2009

Kathleen B. Bechtol
Affiliation:
The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104 USA
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The various lethal t-haplotypes are divided into several complementation groups defined by lethality of tx/ty heterozygotes, and only partial complementation is usually observed in heterozygotes between t complementation groups. Several effects of the t region have been found to be preferentially or exclusively detectable in males. This paper describes results showing that the viability of t6/tw5 heterozygotes is influenced by the sex of the embryo; female viability is only slightly reduced (viability ratio approximately 0·80), while male viability is far below normal (0·25).

Type
Research Article
Copyright
Copyright © Cambridge University Press 1982

References

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