Behavioral and Brain Sciences


Short Communication

Context, connection, and coordination: The need to switch


Robert D. Oades a1, Bernd Röpcke a1 and Ljubov Oknina a2

a1 Clinic for Child and Adolescent Psychiatry, University of Essen, D-45147 Essen, Germany oades@uni-essen.de bernd.roepcke@uni-essen.de www.biopsychology.uni-essen.de
a2 Clinic for Child and Adolescent Psychiatry, University of Essen, D-45147 Essen, Germany; Institute of Higher Nervous Activity and Neurophysiology, Moscow ljubov.oknina@uni-essen.de

Abstract

Context, connection, and coordination (CCC) describe well where the problems that apply to thought-disordered patients with schizophrenia lie. But they may be part of the experience of those with other symptom constellations. Switching is an important mechanism to allow context to be applied appropriately to changing circumstances. In some cases, NMDA-voltage modulations may be central, but gain and shift are also functions that monoaminergic systems express in CCC.