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Is subline differentiation a continuing process in inbred strains of mice?

Published online by Cambridge University Press:  14 April 2009

Yong Hoi-Sen
Yong Hoi-Sen
Affiliation:
Department of Animal Genetics, University College London
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Summary

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Two new sublines of the C57BL/Gr strain of mice have been studied which were derived from earlier sublines in which no genetic variance could be demonstrated. The incidence of some 31 minor skeletal variants was examined which could thus go up or down. As new subline differences have arisen with about the same frequency and mean magnitude of effect as in the past, there is no doubt that, at least in the C57BL strain, subline differentiation is a continuing process. Its high frequency (about 0·01 changes per character at risk per generation) is difficult to reconcile with spontaneous mutation rates of single genes in the mouse. The possibility must thus be considered that some other self-perpetuating processes or entities of some degree of stability are handed down in the lines of descent in which they have arisen, or perhaps become unmasked. There is no reason to suppose that this type of event is confined to inbred strains (in which it can be demonstrated fairly easily); it presumably occurs similarly in mixed stocks in which it would scarcely be detectable.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 1 , February 1972 , pp. 53 - 59
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Beardmore, J. A. (1970). Viral components in the genetic background? Nature 226, 766–767.CrossRefGoogle ScholarPubMed
Carpenter, J. R., Grüneberg, H. & Russell, E. S. (1957). Genetical differentiation involving morphological characters in an inbred strain of mice. II. American branches of the C57BL and C57BR strains. Journal of Morphology 100, 377–388.CrossRefGoogle Scholar
Deol, M. S., Grüneberg, H., Searle, A. G. & Truslove, G. M. (1957). Genetical differentiation involving morphological characters in an inbred strain of mice. I. A British branch of the C57BL strain. Journal of Morphology 100, 345–376.CrossRefGoogle Scholar
Deol, M. S., Grüneberg, H., Searle, A. G. & Truslove, G. M. (1960). How pure are our inbred strains of mice? Genetical Research 1, 50–58.CrossRefGoogle Scholar
Deol, M. S. & Thuslove, G. M. (1957). Genetical studies on the skeleton of the mouse. XX. Maternal physiology and variation in the skeleton of C57BL mice. Journal of Genetics 55, 288–312.CrossRefGoogle Scholar
Green, E. L. (1953). A skeletal difference between sublines of the C3H strain of mice. Science 117, 81–82.CrossRefGoogle ScholarPubMed
Grewal, M. S. (1962). The rate of genetic divergence of sublines in the C57BL strain of mice. Genetical Research 3, 226–237.CrossRefGoogle Scholar
Grüneberg, H. (1954). Variation within an inbred strain of mice. Nature 173, 674–676.CrossRefGoogle Scholar
Grüneberg, H. (1955). Genetical studies on the skeleton of the mouse. XV. Relations between major and minor variants. Journal of Genetics 53, 515–535.CrossRefGoogle Scholar
Grüneberg, H. (1963). The Pathology of Development. A Study of Inherited Skeletal Disorders in Animals. Oxford: Blackwell Scientific Publications.Google Scholar
Grüneberg, H. (1970). Is there a viral component in the genetic background? Nature 225, 39–41.CrossRefGoogle Scholar
Schlager, G. & Dickie, M. M. (1967). Spontaneous mutations and mutation rates in the house mouse. Genetics 57, 319–330.CrossRefGoogle ScholarPubMed