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Developmental ‘Noise‘ and a congenital malformation

Published online by Cambridge University Press:  14 April 2009

Morton S. Adams  and
Jerry D. Niswander
Morton S. Adams
Affiliation:
Human Genetics Branch, National Institute of Dental Research, Bethesda, Maryland 20014
Jerry D. Niswander
Affiliation:
Human Genetics Branch, National Institute of Dental Research, Bethesda, Maryland 20014
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Non-directional asymmetry of paired organs is attributed to developmental ‘noise’. The level of asymmetry is inversely correlated to the degree of developmental stability. Children affected with familial cleft lip ± cleft palate have an increased asymmetry of their dermatoglyphics and molar teeth. The action of polygenes with a quasi-continuous distribution is consistent with this observation.

Type
Short Papers
Information
Genetics Research , Volume 10 , Issue 3 , December 1967 , pp. 313 - 317
Copyright
Copyright © Cambridge University Press 1967

References

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