Journal of the International Neuropsychological Society

Journal of the International Neuropsychological Society (2008), 14:2:209-221 Cambridge University Press
Copyright © 2008 The International Neuropsychological Society
doi:10.1017/S1355617708080570

Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia


S. KRISTIAN  HILL  a1 c1 , JOHN A.  SWEENEY  a1 , ROBERT M.  HAMER  a2 a3 , RICHARD S.E.  KEEFE  a4 , DIANA O.  PERKINS  a2 , HONGBIN  GU  a2 , JOSEPH P.  MCEVOY  a4 and JEFFREY A.  LIEBERMAN  a5
a1 Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois
a2 Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina
a3 Department of Biostatistics, University of North Carolina School of Public Health, Chapel Hill, North Carolina
a4 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina
a5 Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, New York

Article author query
hill sk   [PubMed][Google Scholar] 
sweeney ja   [PubMed][Google Scholar] 
hamer rm   [PubMed][Google Scholar] 
keefe rs   [PubMed][Google Scholar] 
perkins do   [PubMed][Google Scholar] 
gu h   [PubMed][Google Scholar] 
mcevoy jp   [PubMed][Google Scholar] 
lieberman ja   [PubMed][Google Scholar] 

Abstract

Efficient and reliable assessments of cognitive treatment effects are essential for the comparative evaluation of procognitive effects of pharmacologic therapies. Yet, no studies have addressed the sensitivity and efficiency with which neurocognitive batteries evaluate cognitive abilities before and after treatment. Participants were primarily first episode schizophrenia patients who completed baseline (n = 367) and 12-week (n = 219) assessments with the BACS (Brief Assessment of Cognition in Schizophrenia) and CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) neuropsychological batteries in a clinical trial comparing olanzapine, quetiapine, and risperidone. Exploratory factor analysis revealed that performance on both batteries was characterized by a single factor of generalized cognitive deficit for both baseline performance and cognitive change after treatment. Both batteries estimated similar levels of change following treatment, although the BACS battery required half the administration time. Because a unitary factor characterized baseline cognitive abilities in early psychosis as well as cognitive change after treatment with atypical antipsychotic medications, short batteries such as the BACS may efficiently provide sufficient assessment of procognitive treatment effects with antipsychotic medications. Assessment of cognitive effects of adjunctive therapies targeting specific cognitive domains or impairments may require more extensive testing of the domains targeted to maximize sensitivity for detecting specific predicted cognitive outcomes. (JINS, 2008, 14, 209–221.) a

(Received January 22 2007)
(Revised September 12 2007)
(Accepted September 17 2007)


Key Words: Schizophrenia; Neuropsychology; Antipsychotics; Cognition; Clinical trials methodology; CATIE; BACS.

Correspondence:
c1 Correspondence and reprint requests to: Dr. S. Kristian Hill, University of Illinois at Chicago, Center for Cognitive Medicine, Department of Psychiatry (M/C 913), 912 South Wood Street, Suite 235, Chicago, IL 60612. E-mail: shill@psych.uic.edu


Footnotes

a Presented in part at the annual International Neuropsychology Society meeting in Portland, OR, February 2007; and the 2007 International Congress for Schizophrenia Research in Colorado Springs, CO.



null