a1 Metabolic Research Laboratory, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
a2 Department of Medicine, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55108, USA
a3 Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St Paul, MN 55455, USA
In subjects with untreated type 2 diabetes, we previously determined that a weight-maintenance, non-ketogenic diet containing 30 % protein, 50 % fat and 20 % carbohydrate (30:50:20) decreased the percentage total glycohaemoglobin (%tGHb) by 2·2 % glycohaemoglobin over 5 weeks compared to a diet recommended for the American public (protein–fat–carbohydrate 15:30:55). Both the fasting and postprandial glucose were decreased. The objective of the present study was to determine if increasing the carbohydrate content from 20 to 30 % at the expense of fat would still provide a similar effect on %tGHb, fasting and postprandial glucose concentration. Eight men with untreated type 2 diabetes were studied over a 5-week period. Results at the beginning (standard diet) and end of the 5-week study were analysed. Body weight was stable. Fasting glucose concentration decreased by 40 %; 24 h glucose area response decreased by 45 %. Insulin did not change. Mean %tGHb decreased by 1·7 (from 10·8 to 9·1 %), and was still decreasing linearly at 5 weeks. In conclusion, a high-protein, 30 % carbohydrate diet could be a patient-empowering method of improving the hyperglycaemia of type 2 diabetes without pharmacologic intervention. Long-term effects and general applicability of this diet remain to be determined.
(Received April 23 2007)
(Revised June 22 2007)
(Accepted July 25 2007)
Abbreviations: LoBAG30, Low Biologically Available Glucose Diet with 30 % carbohydrate; SDTU, special diagnostic and treatment unit; %tGHb, percentage total glycohaemoglobin