CJO - Abstract - Seroepidemiology of hepatitis A in voluntary blood donors from Pune, western India (2002 and 2004–2005)

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    Seroepidemiology of hepatitis A in voluntary blood donors from Pune, western India (2002 and 2004–2005)
    P. S. GADGIL, R. S. FADNIS, M. S. JOSHI, P. S. RAO and S. D. CHITAMBAR (2008).
    Epidemiology and Infection, Volume 136, Issue 03, March 2008 pp 406-409 http://journals.cambridge.org/action/displayAbstract?aid=1687944

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Epidemiology and Infection (2008), 136 : 406-409 Cambridge University Press
doi:10.1017/S0950268807008643 (About doi)
Published online by Cambridge University Press 07 Jun 2007
 
Cambridge Journals Online - CUP Full-Text Page
Epidemiology and Infection (2008), 136:406-409 Cambridge University Press
Copyright © Cambridge University Press 2007
doi:10.1017/S0950268807008643

Short Report

Seroepidemiology of hepatitis A in voluntary blood donors from Pune, western India (2002 and 2004–2005)

P. S. GADGILa1, R. S. FADNISa1, M. S. JOSHIa1, P. S. RAOa2 and S. D. CHITAMBARa1 c1

a1 National Institute of Virology, Pune – 411001, India
a2 Blood Bank, Inlaks and Budhrani Hospital, and Sahayadri Speciality Hospital Pune – 411001, India
Article author query
gadgil ps PubMed  Google Scholar
fadnis rs PubMed  Google Scholar
joshi ms PubMed  Google Scholar
rao ps PubMed  Google Scholar
chitambar sd PubMed  Google Scholar

SUMMARY

Recently, a changing pattern of hepatitis A epidemiology has been reported in the Indian population indicating a rise in the rate of hepatitis A infection among adults. The study's objective was to assess anti-HAV prevalence in voluntary blood donors from middle and high socioeconomic strata. Serum samples collected from voluntary blood donors from Pune city and its suburbs in the years 2002 and 2004–2005 were tested for anti-HAV IgG antibodies. Serum samples collected during 2004–2005 were examined for anti-HAV IgM antibodies. Positive samples were tested for HAV-RNA. Agewise anti-HAV positivity was significantly low in adults aged 18–25 years (90·4%) compared to those aged >25 years (97·4%) (P<0·01). A decline in anti-HAV prevalence was significant in 2004–2005 compared to that in 2002 (96·5% vs. 92·1%) (P<0·01). Overall, in both adult age groups, the proportion of anti-HAV positivity was remarkably low in the high socioeconomic group (HSG) (88·96%) compared to that of the middle socioeconomic group (MSG) (95·86%) (P<0·01). Anti-HAV IgM positivity was not significant (~1%), however, presence of HAV-RNA in one of the samples indicated the possibility of horizontal transmission of HAV. Increase in seronegativity to HAV in HSG implicates a rise in the susceptible pool and indicates the need for vaccination against hepatitis A.

(Accepted April 03 2007)

(Online publication June 07 2007)

Correspondence:

c1 Author for correspondence: Dr (Mrs) S. D. Chitambar, Deputy Director & HOD, Rotavirus Group, National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune – 411001, India. (Email: chitambars@hotmail.com)

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