Expert Reviews in Molecular Medicine

 



Review Article

Mechanisms of cell entry by influenza virus


Karen J. Cross a1, Laura M. Burleigh a1 and David A. Steinhauer a1c1
a1 National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.

Abstract

A wide range of viruses, including many human and animal pathogens representing various taxonomic groups, contain genomes that are enclosed in lipid envelopes. These envelopes are generally acquired in the final stages of assembly, as viruses bud from regions of the membrane of the infected cell at which virally encoded membrane proteins have accumulated. The viruses procure their membranes during this process and mature particles ‘pinch off’ from the cellular membranes. Under most circumstances, initiation of another round of infection is dependent on two critical functions supplied by the envelope proteins. The virus must bind to cell-surface receptors of a new host cell, and fusion of the viral and cellular membranes must occur to transfer the viral genome into the cell. Enveloped viruses have evolved a variety of mechanisms to execute these two basic functions. Owing to their relative simplicity, studies of binding and fusion using enveloped viruses and their components have contributed significantly to the overall understanding of receptor–ligand interactions and membrane fusion processes – fundamental activities involved in a plethora of biological functions.


Key Words: influenza; haemagglutinin; virus entry; receptor binding; membrane fusion.

Correspondence:
c1 National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK. Tel: +44 (0)20 8959 3666 (ext. 2256); Fax: +44 (0)20 8906 4477; E-mail: dsteinh@nimr.mrc.ac.uk